益气活血法对兔肺心病模型心脏形态的影响

Influence of Yiqihuoxue Treatment on Cardiac Morphology in Rabbit Models of Pulmonary Heart Disease

目的:研究益气活血法治疗兔肺心病模型的心脏形态变化。方法:将32只健康日本大耳白兔按随机数字表分为正常组、模型组、中药治疗组及卡托普利组。模型组、中药治疗组、卡托普利组三氯化铁复制肺心病模型,对中药治疗组、卡托普利组灌胃相应药物各20d,观察造模前、造模后、治疗后家兔全身状况,应用超声心动图观察心脏形态变化。结果:造模后家兔的呼吸频率加快,右室及肺动脉内径增大,右室壁增厚,三尖瓣及肺动脉血流速度降低,超声各参数差异均有统计学意义(P<0.05或P<0.01)。治疗后,中药治疗组的右室及肺动脉主干内径明显减小,差异有统计学意义(P<0.05或P<0.01)。结论:应用益气活血法治疗兔肺心病模型,可以有效缓解症状,减小右心室内径,降低肺动脉压力。

Objective： To investigate the changes of heart morphology after treatment by Yiqihuoxue in rabbit models of pulmonary heart disease. Methods： Thirty-two healthy Japanese white rabbits were randomly divided into 4 groups, normal group （NG）, model group （MG）,Chinese medicine group （CMG） and captopril group （CG）. The rabbit model of pulmonary heart disease was established by giving a single dose of FeCl3 in MG, CMG and CG groups. Rabbits were treated by Yiqihuoxue or captopril for 20 days in CMG and CG groups, respectively. The data of the general condition were observed, and the cardiac morphology was detected by echocardiography before and after treatment in rabbits of groups. Results： It was observed that the respiratory rate accelerated, right ventricular diameter（RVD） and pulmonary artery diameter （PAD） increased, the right ventricular anterior wall （RVAW） thickening, blood flow velocity of tricuspid valve （TV） and pulmonary artery （PV） decreased and ultrasound showed significant differences after establishment of the model in rabbits （P 0.05 or P 0.01）. The values of RVD and PAD were significantly decreased after treatment in rabbits of CMG group than those of other groups （P 0.05）. Conclusion： Yiqihuoxue treatment can alleviate the symptoms effectively, and reduce the RVD and pulmonary artery pressure in rabbit models of pulmonary heart disease.