高脂血症对年龄相关性核性白内障患者晶状体密度影响分析

Study on the lens density of age-related nuclear cataract patients affected by hyperlipidemia

目的 探讨高脂血症对年龄相关性核性白内障患者晶状体密度影响.方法 收集2007年1月至2008年12月在沈阳市第四人民医院眼科就诊的年龄相关性核性白内障患者136例（189只眼）作为研究组.其中,男59例,女77例.年龄51～91岁,平均年龄（71.3±8.6）岁.同时,随机选取同期年龄匹配的90例（180只眼）健康体检者作为对照,年龄54～83岁,平均年龄（68.9±7.4）岁.受检者抽取静脉血后检测进行血清总胆固醇（TC）、甘油三酯（TG）,低密度脂蛋白胆固醇（LDLC）的测定.同时对受检者进行眼科检查,检测其晶状体密度LOCSⅢ分级和LogMAR视力.结果 年龄相关性核性白内障患者的血清TC、TG和LDLC值分别为（6.958＋1.87）mmo1/L、（1.97＋0.71）mmol/L和（4.17＋1.83）mmol/L,均显著高于对照组的（4.26＋0.78）mmol/L、（1.29＋0.48）mmol/L和（2.85＋0.67）mmol/L,组间差异具有统计学意义,P＜0.05.年龄相关性核性白内障患者的晶状体密度、LOCSⅢ分级分值和LogMAR视力均显著高于对照组,两组差异具有统计学意义（P＜0.01）.血清TC、TG和LDLC与年龄相关性核性白内障患者晶状体密度呈正相关,其相关系数r分别为0.671、0.835和0.569.经检验,P＜0.05或0.01.结论 高脂血症能使年龄相关性核性白内障患者晶状体密度增加,是年龄相关性白内障发病的危险因素之一.

Objective To investigate the lens density of age-related nuclear cataract patients affected by hyperlipidemia. Methods A total of 136 cases （189 eyes） of age-related nuclear cataract patients were collected during the treatment from January 2007 to December 2008 in the Department of Ophthalmology, the Fourth People＇s Hospital of Shenyang, Liaoning. There were 39 male cases and 51 female cases, with the range of ages as 51-91, and averaged 71.3±8.6 years old. At the same time, 90 （180 eyes） cases of age-matched healthy persons over the same period were randomly selected as the control, with the range of ages as 54-83,and averaged 68.9±7.4 years old. For each subject, serum total cholesterol （TC）, triglyceride （TG）, low-density lipoprotein cholesterol （LDLC）, were determined after venous blood samples were collected. Meanwhile, eye examinations were performed to determine the lens density of LOCS Ⅲ grading and LogMAR visual acuity.Results The serum TC, TG and LDLC values of age-related nuclear cataract patients were 6.958 ± 1.87 mmol / L, 1.97 ± 0.71 mmol/ L and 4.17±1.83 mmol / L, respectively, which were significantly higher than that of the control group （4.26±0.78 mmol/ L, 1.29±0.48 mmol/ L and 2.85 ± 0.67 mmol/ L） respectively. The difference between two groups was significant （P 〈0.05） or very significant （P 〈0.01）. The lens density, LOCS Ⅲ grading score and LogMAR visual acuity were significantly higher than that of the control group.There were significantly statistical differences between data of two groups （P 〈0.01）. There were significant positive correlation between Serum TC, TG, LDLC and lens density among age-related nuclear cataract patients, the correlation 0.569, respectively （P 〈0.05 or P 〈0.01）. Conclusions Hyperlipemia can increase lens density of age-related nuclear cataract patients, and is a risk factor of age-related cataract.