淫羊藿饮片杂质问题的研究与探讨

Research and discussion on impurity problems in Epimedium cut crude drug

目的:探讨淫羊藿饮片中的杂质问题。方法:检查15批次淫羊藿饮片中各类杂质的含量,并测定淫羊藿饮片各部位中朝藿定A、朝藿定B、朝藿定C、淫羊藿苷和宝藿苷I五种黄酮类成分的含量。结果:15批次淫羊藿饮片杂质平均含量为23.66%,其中非药用部分茎占18.39%,柄占4.22%,其它杂质异物占1.05%,并且茎、柄中5种黄酮类成分的含量为淫羊藿叶中含量的1/10。结论:淫羊藿饮片中茎、柄杂质的大量存在直接导致了饮片整体质量的降低,因此建议在2010版《中国药典》质量标准制订中,将淫羊藿药材的药用部位规定为"干燥叶片",从药材源头开始杜绝非药用部分茎、柄的存在,从而提高淫羊藿药材和饮片的整体质量,保证饮片的纯净度和投药量的准确度,进而确保临床疗效。

Objectve： To discussion the impurity problems in Epimedium cut crude drug. Methods： All kinds of impurity content were investigated in 15 batches Epimedium cut crude drug, and the five flavonoids content were determined in every part. Results： The average impurity content of 15 batches Epimedium cut crude drug was 23.66%. Of the total, stalk reached 18.39%, leafstalk reached 4.22%, and other foreign matters was 1.05%. The five flavonoids content in leaves was l0 times of the content in leafstalks and stalks. Conclusion： The generous leafstalks and stalks impurity have leaded to lower the total body mass of Epimedium cut crude drug. Therefore we suggested that the drug use part of Epimedium medicinal substances should be defined dry leaf in Chinese Pharmacopeia 2010 edition, which can eliminate leafstalks and stalks from source head. This can improve total body mass of medicinal substances and cut crude drug, and ensure the clean degree of cut crude drug and the accurate degree of dosage, thus to ensure clinical curative effect.