期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

c-Met和MMP-2在卵巢上皮癌中的表达及相关性研究 被引量：3

Expression and relevant of c-Met and MMP-2 in epithelial ovarian cancer
下载PDF
导出
摘要 目的探讨肝细胞生长因子受体(c-Met)和基质金属蛋白酶-2(MMP-2)在卵巢上皮癌中的表达特点及生物学行为关系。方法应用免疫组化S-P法检测50例卵巢上皮癌、15例交界性卵巢上皮肿瘤、20例良性卵巢上皮肿瘤及20例正常卵巢组织中c-Met和MMP-2的表达情况。结果 c-Met和MMP-2在卵巢上皮癌中的阳性表达率分别为84.0%和86.0%,与卵巢上皮癌的组织分化和临床分期有关,而与组织类型无关。c-Met和MMP-2表达具有正相关性(P<0.05)。结论 c-Met和MMP-2的表达可能与卵巢上皮癌的发生发展有关,c-Met和MMP-2表达呈正相关,二者可成为观察卵巢上皮癌侵袭进展、转移和预后的指标。 Objective To detect the expression and biological behavior of hepatocyte growth factor receptor（c-Met）and matrix metalloproteinase-2（MMP-2）in epithelial ovarian cancers.Methods The expression of c-Met and MMP-2 were examined by immunohistochemical S-P staining method in 50 cases with epithelial ovarian cancer,15 cases with borderline epithelial ovarian tumors,20 cases with benign epithelial ovarian tumors and 20 cases with normal ovarian tissue.Results The positive expression of c-Met and MMP-2 in epithelial ovarian cancers were 84.0% and 86.0% and they were related to the pathological and clinical stage,but had no relationship with histological type.There was positive correlation between the expression of c-Met and MMP-2（P0.05）.Conclusions The expression of c-Met and MMP-2 were closely related to the progress of epithelial ovarian cancer which might be useful factors of proliferation,metastasis and prognosis of epithelial ovarian cancer.
作者 俞维
机构地区 洛阳东方医院
出处 《中国妇产科临床杂志》 2010年第6期440-442,共3页 Chinese Journal of Clinical Obstetrics and Gynecology
关键词 卵巢上皮癌 C-MET MMP-2 免疫组织化学 epithelial ovarian cancer c-Met MMP-2 immunohisto-chemistry
分类号 R737.31 [医药卫生—肿瘤]
  • 相关文献

参考文献3

二级参考文献56

  • 1Royal I, Park M. Hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells require phosphatidylinositol 3-kinase. J Biol Chem 1995; 270:27780-7.
  • 2Xiao GH, Jeffers M, Bellacosa A, et al. Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways.Proc Natl Acad Sci U S A 2001; 98:247-52.
  • 3Stefan M, Koch A, Mancini A, et al. Src homology 2-containing inositol 5-phosphatase 1 binds to the multifunctional docking site of c-Met and potentiates hepatocyte growth factor-inducedbranching tubulogenesis. J Biol Chem 2001; 276:3017-23.
  • 4Boccaccio C, Ando M, Tamagnone L, et al. Induction of epithelial tubules by growth factor HGF depends on the STAT pathway.Nature 1998; 391:285-8.
  • 5Zhang YW, Wang LM, Jove R, et al. Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis. Oncogene 2002;21:217-26.
  • 6Jeffers M, Taylor GA, Weidner KM, et al. Degradation of the Met tyrosine kinase receptor by the ubiquitin-proteasome pathway. Mol Cell Biol 1997; 17:799-808.
  • 7Petrelli A, Gilestro GF, Lanzardo S, et al. The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of cMet. Nature 2002; 416:187-90.
  • 8Lee CC, Putnam AJ, Miranti CK, et al. Overexpression of sprouty 2 inhibits HGF/SF-mediated cell growth, invasion, migration,and cytokinesis. Oncogene 2004; 23:5193-202.
  • 9Birchmeier W, Brinkmann V, Niemann C, et al. Role of HGF/SF and c-Met in morphogenesis and metastasis of epithelial cells.Ciba Found Symp 1997; 212:230-40; discussion 240-6.
  • 10Shinomiya N, Gao CF, Xie Q, et al. RNA interference reveals that ligand-independent Met activity is required for tumor cell signaling and survival. Cancer Res 2004; 64:7962-70.

共引文献67

同被引文献19

  • 1Kirchhofer D,Lipari MT,Santell L,et al.Utilizing the activation mechanism of serine proteases to engineer hepatocyte growth factor into a Met antagonist[J].Proc Natl Acad Sci U S A,2007,104(13):5306-5311.
  • 2Ketterer K,Kong B,Frank D,et al.Neuromedin U is overexpressed in pancreatic cancer and increases invasiveness via the hepatocyte growth factor c-Met pathway[J].Cancer Lett,2009,277(1):72-81.
  • 3Onimaru Y,Tsukasaki K,Murata K,et al.Autocrine and/or paracrine growth of aggressive ATLL cells caused by HGF and c-Met[J].Int J Oncol,2008,33(4):697-703.
  • 4Puri N,Salgia R.Synergism of EGFR and c-Met pathways,cross-talk and inhibition,in non-small cell lung cancer[J].J Carcinog,2008,7:9-9.
  • 5Bongiovanni L, di Diodoro F, Della Salda L,et al. On the role of survivin as a stem cell biomarker of canine hair follicle and related turnouts[J]. Vet Dermatol, 2014,25 (2) : 138-141.
  • 6Kuku-Cabuk F, Yiqit S, Demir L,et al. Correlation of sur- vivin and MMP-9 expressions with prognosis and elinieopath- ological parameters in surface epithelial ovarian carcinomas [J]. Turk Patoloji Derg,2014,30(1) :30-37.
  • 7Umemori Y, Kuribayashi K, Nirasawa S, et al. Protein ki- nase C regulates survivin expression and inhibits apoptosis in colon eancer[-J-I. Int J Oncol, 2014,45 (3) : 1043-1050.
  • 8胡明泰,哈小琴,高鹏.肝细胞生长因子拮抗剂NK4抑制肿瘤的机制[J].第四军医大学学报,2008,29(1):86-88. 被引量：4
  • 9刘增进,夏祥国.肝细胞生长因子及其受体在肿瘤中的研究进展[J].医学信息（手术学分册）,2007,20(11):1015-1018. 被引量：3
  • 10王延飞,蒲章杰,尹广文,牛克峰.HGF/C-Met系统与头颈部肿瘤研究进展[J].中国实用医药,2008,3(3):135-137. 被引量：2

引证文献3

二级引证文献13

中国妇产科临床杂志
2010年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部