卵巢上皮性肿瘤中c-myc和CD44v6的表达及其临床意义

Expression of c-myc and CD44v6 in epithelial ovarian tumor and their clinical significance

目的探讨c-myc及CD44v6蛋白在卵巢上皮性肿瘤中的表达及其临床意义。方法应用免疫组化法检测67例卵巢上皮性肿瘤及10例正常卵巢组织中c-myc、CD44v6的表达。结果恶性卵巢上皮性肿瘤中c-myc和CD44v6基因蛋白的阳性表达率分别为62.2%和26.7%,c-myc蛋白基因的表达在卵巢良性、交界性及恶性肿瘤间差异显著(P<0.05);但CD44v6的表达差异不显著(P>0.05)。不同组织学类型、分化程度及临床分期的卵巢癌中c-myc的表达差异不显著(P>0.05)。CD44v6的表达与卵巢肿瘤的组织学类型及临床分期无关,但与肿瘤的分化程度有关,且随分化程度的降低而增强。c-myc与CD44v6的表达具有相关性(P<0.05)。结论卵巢肿瘤组织中c-myc的表达与卵巢癌的发生有密切关系,提示c-myc可作为卵巢癌的肿瘤标记物;而CD44v6参与卵巢肿瘤的发生、发展。c-myc与CD44v6在卵巢肿瘤的发生、发展中可能起协同作用。

Objective To investigate the expression of c-myc protein and CD44v6 in epithelial ovarian tumor and to discuss their clinical significance. Methods The expression of c-myc and CD44v6 was detected by immunohistochemistry in 77 cases of ovarian epithelial tumors and normal ovarian tissue. Re.quits The positive rate of c- myc expression in malignant ovarian epithelial tumor was 62. 2% , significantly higher than that of benign and borderline ovarian epithelial tumor （P 〈 0.05 ）. The positive rate of CD44v6 expressionin in malignant ovarian epithelial tumor was 26. 7%, which had not correlated with histological type and clinical stage of epithelial ovarisn cancer （ P 〉 0. 05 ）, but were significantly related to the differentiation grade （ P 〈 0. 05 ）. The expression of c-myc was, significantly related to that of CD44v6. Conclusion The expression of c-myc is significantly related to the pathogenesis of ovarian cancer, suggesting that C-myc can be used as a marker for ovarian cancer tumor; CD44v6 may involve in the occurrence and development of ovarian cancer,in which c-myc may play a synergistic role.