推拿对慢性疲劳综合征患者氧自由基代谢的影响

Effect of Tuina on oxygen free radicals metabolism in patients with chronic fatigue syndrome

目的:探讨推拿对慢性疲劳综合征患者的作用机制。方法:将90例患者随机分为推拿组、太极拳组、氟西汀组,每组30例,分别采用推拿、太极拳训练和口服氟西汀治疗,1月后,观察3组疗效及血清丙二醛(MDA)含量、血清超氧化物歧化酶(SOD)、血清谷胱甘肽过氧化物酶(GSH-Px)活性变化。结果:推拿组总有效率93.3%(28/30)与太极拳组80.0%(24/30)和氟西汀组73.3%(22/30)相比,差异均有统计学意义(均P<0.05);治疗后3组血清MDA含量较治疗前均降低(P<0.01,P<0.05),SOD、GSH-Px活性推拿组、太极拳组较治疗前升高(P<0.01,P<0.05),推拿组升高更显著,与太极拳组、氟西汀组比较,差异有统计学意义(P<0.05,P<0.01)。结论:推拿组治疗慢性疲劳综合征疗效优于太极拳组和氟西汀组;推拿治疗的作用机制可能是调节患者氧自由基代谢,清除体内多余的氧自由基,从而达到缓解疲劳的目的。

Objective To explore the mechanism of Tuina for treatment of chronic fatigue syndrome. Methods A total of 90 patients were randomly divided into a Tuina group, a Taijiquan （take exercise） group and a Fluoxetine group, 30 cases in each group. They were treated with Tuina, Taijiquan and Fluoxetine, respectively. After a month, the therapeutic effects and the changes of malondialdehyde （MDA） content and the activity of serum supe roxide dismutases （SOD） and serum glutathione peroxidase （GSH-Px） were observed. Results The total effective rate of 93.3% （28/30） in the Tuina group was better than 80.0% （24/30） in the Taijiquan group and 73.3% （22/ 30） in the Fluoxetine group （both P〈0. 05）. After treatment, MDA contents in the three groups were all decreased （P〈0.01, P〈0.05）, and the activity of SOD, GSH-Px in both the Tuina group and the Fluoxetine group were increased（P〈0.01, P〈0.05）, and especially in the Tuina group with a significant difference as compared with the other two groups （P〈0.05,P〈0.01）. Conclusion The therapeutic effect of the Tuina group is superior to that of the Taijiquan group and the Fluoxetine group. Tuina can regulate oxygen free radicals metabolism and clean superfluous oxygen free radicals to alleviate fatigue, which may be one of the mechanisms of Tuina in treating chronic fatigue syndrome.