褪黑激素镇痛和镇静的某些研究进展

Progress of melatonin in analgesia and sedation

褪黑激素不仅能使入睡容易、改善睡眠质量，减轻术前焦虑、产生镇静，调节昼夜节律，抗衰老，免疫调节，以及产生抗惊厥和抗炎作用，而且对疼痛的调节也起重要作用。研究表明，在急性疼痛、炎性痛及神经性疼痛等多种疼痛类型中，褪黑激素能预防、减轻伤害性疼痛，可用于治疗纤维肌痛、外科手术相关疼痛，以及防治术后谵妄或时差综合征等。

Melatonin not only facilitate the onset and promote the quality of sleep, alleviate preoperative anxiety and produce sedation, regulate circadian rhythms, delay caducity and keep immunoregulation, produce anticonvulsant and anti-inflammatory effects, but also play an important role in pain modulation. It has been shown that melatonin can prevent and reduce nociceptive pain in different models of pain such as acute pain,inflammatory pain and neuropathic pain. Melatonin can be used for alleviating pain associated with fibromyalgia or surgical procedures, treating and preventing of postoperative delirium or jet lag and so on.