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CD4^＋T淋巴细胞内三磷腺苷检测法及其在器官移植中的应用

CD4^＋ T lymphocytes intracellular adenosine triphosphate assay （Immuknow assay）and its application in solid organ transplantation
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摘要 CD4^＋T细胞内ATP水平可反映其活化程度。Immuknow免疫细胞功能检测法，通过定量检测CD4^＋T细胞内ATP的含量，来评估CD4^＋T细胞的活化程度，进而评价机体的免疫状态。该检测法目前已应用于监测临床移植物受者免疫状态，可减少移植物活检频率，以及指导免疫抑制剂的个体化应用。 Immuknow-cylex immune function assay, by measuring the content of adenosine triphosphate（ATP） produced in CD4^＋ T lymphocytes, could assess the degree of activation of CD4^＋T lymphocytes and the immune function of allograft recipients. Results of this assay correlate well with the immune status of transplant recipients. Currently, this assay has been applied to monitoring the immune status of transplant recipients. Its application in this area has reduced the frequency of biossy-taking of allograft and can be used to guide the individualized utilization of immunosuppressant.
作者 李春景 周佩军
机构地区 上海交通大学附属瑞金医院泌尿外科
出处 《国际免疫学杂志》 CAS 北大核心 2010年第6期450-454,共5页 International Journal of Immunology
关键词 ATP CD4^+T细胞 移植物受者 免疫功能 ATP CD4^＋ T lymphocyte Transplant recipient Immune function
分类号 R [医药卫生]
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参考文献33

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共引文献12

国际免疫学杂志
2010年 第6期

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