MTA1和KAI1蛋白在声门上型喉癌组织中的表达及其临床意义

Expression and significance of MTA1 and KAI1 in carcinoma of supraglottic larynx

目的探讨肿瘤转移相关基因1(MTA1)和肿瘤转移抑制基因1(KAI1)在声门上型喉癌组织中的表达及其与临床病理特征的关系。方法选取60例声门上型喉癌患者手术切除的病理组织标本(实验组)及20例癌旁组织标本(对照组),应用免疫组织化学法检测MTA1和KAI1蛋白的表达。结果实验组MTA1蛋白表达阳性率高于对照组(P<0.05),KAI1蛋白表达阳性率低于对照组(P<0.05);实验组MTA1蛋白阳性表达率38.3%,明显高于于对照组的0%,且与喉癌组织分级、临床分期和淋巴结转移关系密切(P<0.05);实验组KAI1蛋白阳性表达率为40.0%,明显低于对照组的75.0%,且与喉癌的淋巴结转移密切相关(P<0.05);但在不同年龄、性别、临床分期及组织分级的患者之间,表达差异无统计学意义(P>0.05)。喉癌组织中MTAl蛋白与KAI1蛋白表达呈负相关(P<0.05)。结论 MTA1和KAI1的表达在声门上型喉癌的淋巴结转移过程中具有一定作用,可作为预测肿瘤转移潜能指标。

Objective To observe the expressions of MTA1 and KAI1 in carcinoma of supraglottic larynx and its relationship with clinicopathological features.Methods The expressions of MTA1 and KAI1 in 60 patients with carcinoma of supraglottic larynx（group A）and 20 tumor-adjacent tissues（group B）were detected by immunohistochemistry.Results The expression of MTA1 protein was higher,but that of KAI1 was lower,in group A than that in group B [38.3% vs.0% and 40.0% vs.75.0%]（P0.05）.The positive rate of MTA1 was 38%,which was related to degree of pathological differentiation,sex,clinical stage and lymph node metastasis（P0.05）.The positive rate of KAI1 was 40%,which was related to lymph node metastasis.There were no significant differences in the expressions of MTA1 and KAI1 in carcinoma of supraglottic larynx among pathological differentiation,sex and clinical stage（P0.05）.The expression of MTA1 was negatively correlated to that of KAI1 in group A（P0.05）.Conclusion MTA1 and KAI1 may play an important role in metastasis of carcinoma of supraglottic larynx and could be taken as the potential markers for tumor metastasis.