前列地尔对大鼠移植肝肝功能的影响

Effect of lipo-prostaglandin E1 on hepatic function of orthotopic liver transplantation in rats

目的探讨前列地尔对冷保存2、4h的移植肝肝功能的影响。方法 64只雄性SD大鼠,随机均分为4组:A1组(供肝冷缺血2h)、A2组(供肝冷缺血2h,静脉注射前列地尔2μg/kg)、B1组(供肝冷缺血4h)和B2组(供肝冷缺血4h,静脉注射前列地尔2μg/kg)。门静脉复流6h后,检测胆汁流量和血浆中ALT、AST、LDH。结果术后6h,A2组和B2组胆汁分泌量均多于各自对照组(P<0.05),但ALT、AST、LDH水平均低于各自对照组(P<0.05)。结论前列地尔可以改善受体大鼠术后肝功能。

Objective To investigate the effect of lipo-prostaglandin E1（lipo-PGE1）on the function of transplanted liver preserved in cold condition for 2 or 4h.Methods Sixty-four SD male rats were equally divided into 4 groups of A1（cold ischemia 2h）,A2（cold ischemia 2h followed by intravenous injection with lipo-PGE1 2μg/kg）,B1（cold ischemia 4h）and B2（cold ischemia 4h followed by intravenous injection with lipo-PGE1 2μg/kg）.After 6h of the portal vein reperfusion,the volumes of choleresis and the levels of ALT,AST,LDH were detected.Results After 6 h of the portal vein reperfusion,the volumes of choleresis in groups of A2 and B2 were higher than those in respective control groups（P0.05）,but the levels of ALT,AST,LDH were all lower（P0.05）.Conclusion Lipo-PGE1 can improve the hepatic function of recipients after orthotopic liver transplantation in rats.