慢性乙型肝炎抗病毒的优化治疗策略

Optimal strategy for antiviral therapy of chronic hepatitis B

乙型肝炎病毒(HBV)感染可导致慢性肝炎,并可以发展为肝硬化、肝癌而导致死亡,在我国HBV感染人数众多.抗乙型肝炎病毒治疗是控制病情进展的关键,但目前上市的抗乙型肝炎病毒药物疗效尚不够理想,需要进一步通过优化治疗策略以提高长期疗效,降低耐药发生率.目前优化治疗策略主要是根据患者基线特征进行方案选择和利用路线图概念,根据治疗中早期病毒学应答调整治疗方案.

Hepatitis B virus （HBV） infection can induce cirrhosis and liver cancer to result in death.There are a considerable number of HBV-infected people in China.Antiviral therapy is key to disease control.However,the curative effect of currently available antiviral drugs for chronic hepatitis B is not ideal.Antiviral therapy should be optimized to improve the efficacy and reduce the incidence of drug resistance.At present,optimal therapy strategy involves choosing a therapeutic scheme based on baseline characteristics of the patient and utilizing the roadmap concept to adjust treatment plan according to early virologic response.