摘要
14-3-3蛋白家族是近年来研究较热的一组胞质内酸性蛋白质,目前的研究认为14-3-3蛋白家族主要通过调节肿瘤细胞生长、生存、扩散、迁移、细胞周期、细胞凋亡及细胞信号通路等参与肿瘤的发生发展.在14-3-3蛋白家族中14-3-3σ具有抑癌活性,而其他亚型蛋白则具有促癌活性.本文就近年来有关14-3-3蛋白的改变与肿瘤发病的关系作一综述.
14-3-3 proteins are a family of acidic proteins that are predominantly localized in the cytoplasm.They have been known to play a role in tumorigenesis and tumor progression by regulating tumor cell growth,survival,proliferation,migration,and apoptosis.Of all 14-3-3 proteins,14-3-3σ has tumor-suppressor activity,while other members have tumor-promoting activity.In this paper,we briefly review the role of 14-3-3 proteins in tumor pathogenesis.
出处
《世界华人消化杂志》
CAS
北大核心
2010年第28期2997-3002,共6页
World Chinese Journal of Digestology
基金
上海市科委基金资助项目
No.07DZ19505~~
