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成纤维细胞生长因子21与糖脂代谢的研究进展 被引量：1

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摘要 成纤维细胞生长因子（FGF）具有激素样作用，人类的FGF家族包括22个成员，按种系和序列又分为7个亚科，大部分FGF因子对细胞的生长和分化具有调节作用。成纤维细胞生长因子21（FGF-21）是新近发现的FGF家族新成员，是在细胞因子功能高通量筛查以发掘新型糖尿病治疗药物的研究中被首次发现，其全长209个氨基酸，
作者 于浩泳 贾伟平
机构地区 上海交通大学附属第六人民医院内分泌代谢科上海市糖尿病临床医学中心上海市糖尿病研究所
出处 《中华医学杂志》 CAS CSCD 北大核心 2010年第42期3019-3021,共3页 National Medical Journal of China
基金 基金项目：上海市糖尿病重点实验室建设（08DZ2230200）
关键词 成纤维细胞生长因子 糖脂代谢 FGF家族 糖尿病治疗药物 激素样作用 细胞因子 高通量 氨基酸
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献28

  • 1Nishimura T,Nakatake Y,Konishi M,et al.Identification of a novel FGF,FGF-21,preferentially expressed in the liver.Biochim Biophys Acta,2000,1492:203-206.
  • 2Wente W,Efanov AM,Brenner M,et al.Fibroblast growth factor21 improves pancreatic β-cell function and survival by activation of extracellular signalre-gulated kinase 1/2 and Akt signaling pathways.Diabetes,2006,55:2470-2478.
  • 3Kharitonenkov A,Shiyanova TL,Koester A,et al.FGF-21 as a novel metabolic regulator.J Clin Invest,2005,115:1627-1635.
  • 4Ogawa Y,Kurosu H,Yamamoto M,et al.BetaKlotho is required for metabolic activity of fibroblast growth factor 21.Proc Natl Acad Sci USA,2007,104:7432-7437.
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同被引文献15

  • 1Berti L,Irmler M,Zdichavsky M,et al.Fibroblast growth factor 21 is elevated in metabolically unhealthy obesity and affects lipid deposition,adipogenesis,and adipokine secretion of human abdominal subcutaneous adipocytes[J].Molecular Metabolism,2015,4(7):519-527.
  • 2Slusher A L,Whitehurst M,Zoeller R F,et al.Attenuated fibroblast growth factor 21 response to acute aerobic exercise in obese individuals[J].Nutrition,Metabolism,and Cardiovascular Diseases,2015,25(9):839-845.
  • 3Grunwald T,De Luca F.Role of fibroblast growth factor 21 (FGF21) in the regulation of statural growth[J].Current Pediatric Reviews,2015,11(2):98-105.
  • 4Inagaki T,Dutchak P,Zhao G,et al.Endocrine regulation of the fasting response by PPAR α-mediated induction of fibroblast growth factor 21[J].Cell Metabolism,2007,5(6):415-425.
  • 5Badman M K,Koester A,Flier J S,et al.Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis[J].Endocrinology,2009,150(11):4931-4940.
  • 6Coskun T H,Schneider M.Fibroblast growth factor 21 cmxects obesity in mice[J].Endocrinology,2008,149(12):6018-6027.
  • 7Kharitonenkov A,Wroblewski V J,Koester A,et al.The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21[J].Endocrinology,2007,148(2):774-781.
  • 8Kharitonenkov A,Shiyanova T L,Koester A,et al.FGF-21 as a novel metabolic regulator[J].The Journal of Clinical Investigation,2005,115(6):1627-1635.
  • 9Kharitonenkov A,Wroblewski V J,Koester A,et al.The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21[J].Endocrinology,2007,148(2):774-781.
  • 10Badman M K,Pissios P,Kennedy A R,et al.Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states[J].Cell Metabolism,2007,5(6):426-437.

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中华医学杂志
2010年 第42期

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