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DNA甲基化转移酶3B基因和多巴胺D1受体基因交互作用与精神分裂症的关系 被引量：7

Gene-gene interaction between DNMT3B and DRD1 in schizophrenia
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摘要 目的 探讨DNA甲基化转移酶3B（DNMT3B）基因与多巴胺D1受体（DRD1）基因交互作用对精神分裂症患病风险的影响.方法 选取DNMT3B基因2个标签SNP（rs2424908和rs6119954）以及DRD1基因5个标签SNP（rs4532、rs5326、rs2168631、rs6882300和rs267418）,采用TaqMan探针SNP基因分型技术对365例精神分裂症患者和365名健康对照者进行检测,使用多因子降维法软件（MDR）分析基因-基因交互作用.结果 DNMT3B基因rs6119954位点基因型分布在患者组与对照组之间差异有统计学意义（χ2=8.06,P=0.018）;MDR分析结果显示DNMT3B与DRD1基因相互作用存在于两位点模型（rs6119954-rs267418）（OR=1.79,95%CI：1.29～2.47;χ2=12.51,P=0.0004）,三位点模型（rs6119954-rs5326-rs267418）（OR=2.36,95%CI：1.73～3.22;χ2=29.33,P＜0.0001）以及四位点模型（rs2424908-rs6119954-rs5326-rs267418）（OR=3.08,95% CI：2.24～4.24;χ2=48.88,P＜0.0001）.结论 DNMT3B与DRD1基因存在交互作用,并可能增加精神分裂症的发病风险. Objective To identify the impact of gene-gene interaction between DNMT3B and DRD1 on the risk of schizophrenia. Methods Two SNPs （rs2424908 and rs6119954） within DNMT3B and five SNPs （rs4532, rs5326, rs2168631, rs6882300 and rs267418 ） within DRD1 were genotyped in 365 schizophrenic patients and 365 healthy controls. The gene-gene interaction between DNMT3B and DRD1 was analyzed by Multifactor Dimensionality Reduction （MDR） software. Results The frequency of genotypes of rs6119954 within DNMT3B was significantly higher in patients than that in controls （χ2 = 8. 06 ,P =0. 018 ）.MDR revealed that the significance were shown in patterns with 2 SNPs （ rs6119954-rs267418 ） （ OR =1.79, 95% CI：1.29-2.47;χ2 =12.51, P=0.0004） , 3 SNPs （rs6119954-rs5326-rs267418） （OR=2. 36, 95% CI： 1.73 - 3.22;χ2 = 29. 33, P 〈 0. 0001 ） and 4 SNPs （ rs2424908-rs6119954-rs5326-rs267418） （OR=3.08, 95% CI：2.24 -4.24;χ2 =48.88, P〈0. 0001）. Conclusion The gene-gene interaction between DNMT3B and DRD1 may exist and increase the risk for schizophrenia.
作者 张晨 谢斌 杜亚松 范娟 刘漪 禹顺英 方贻儒
机构地区 上海交通大学医学院附属精神卫生中心
出处 《中华医学杂志》 CAS CSCD 北大核心 2010年第43期3059-3062,共4页 National Medical Journal of China
基金 国家自然科学基金（30500181） 上海市自然科学基金（10ZR1425700）
关键词 DNA甲基化转移酶3B 多巴胺D1受体 基因-基因交互作用 精神分裂症 DNA methyltransferase 3B Dopamine D1 receptor Gene-gene interaction Schizophrenia
分类号 R686 [医药卫生—骨科学]
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参考文献13

  • 1Sullivan PF,Kendler KS,Neale MC.Schizophrenia as a complex trait:evidence from a meta-analysis of twin studies,Arch Gen Psychiatry,2003,60:1187-1192.
  • 2Abdolmaleky HM,Cheng KH,Faraone SV,et al.Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder.Hum Mol Genet,2006,15:3132-3145.
  • 3Allen NC,Bagade S,McQueen MB,et al.Systematic metaanalyses and field synopsis of genetic association studies in schizophrenia:the SzGene database.Nat Genet,2008,40:827-83.
  • 4Zhang C,Fang YR,Xie B,et al.No genetic association between dopamine D1 receptor gene and[early onset] schizophrenia.Psychiatry Res,2010,177:350-353.
  • 5Zhang C,Fang YR,Xie B,et al.DNA methyltransferase 3B gene increases risk of early onset schizophrenia.Neurosci Lett,2009,462:308-311.
  • 6Cheng X,Blumenthal RM.Mammalian DNA methyltransferases:a structural perspective.Structure,2008,16:341-350.
  • 7唐迅,李娜,胡永华.应用多因子降维法分析基因-基因交互作用[J].中华流行病学杂志,2006,27(5):437-441. 被引量：30
  • 8Howes OD,Kapur S.The dopamine hypothesis of schizophrenia:version Ⅲ-the final common pathway.Schizophr Bull,2009,35:549-562.
  • 9Rybakowski JK,Borkowska A,Czerski PM,et al.An association study of dopamine receptors polymorphisms and the Wisconsin Card Sorting Test in schizophrenia.J Neural Transm,2.
  • 10McGowan S,Lawrence AD,Sales T,et al.Presynaptic dopaminergic dysfunction in schizophrenia:a positron emission tomographic[18F]fluorodopa study.Arch Gen Psychiatry,2004,61.

二级参考文献13

  • 1Moore JH.The ubiquitous nature of epistasis in determining susceptibility to common human diseases.Hum Hered,2003,56:73-82.
  • 2Moore JH,Ritchie MD.The challenges of whole-genome approaches to common diseases.JAMA,2004,291:1642-1643.
  • 3Ritchie MD,Hahn LW,Roodi N,et al.Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer.Am J Hum Genet,2001,69:138-147.
  • 4Hahn LW,Ritchie MD,Moore JH.Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions.Bioinformatics,2003,19:376-382.
  • 5Nelson MR,Kardia SL,Ferrell RE,et al.A combinatorial partitioning method to identify multilocus genotypic partitions that predict quantitative trait variation.Genome Res,2001,11:458-470.
  • 6Coffey CS,Hebert PR,Ritchie MD,et al.An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene interactions on risk of myocardial infarction:the importance of model validation.BMC Bioinformatics,2004,5:49.
  • 7Moore JH.Computational analysis of gene-gene interactions using multifactor dimensionality reduction.Expert Rev Mol Diagn,2004,4:795-803.
  • 8Robnik-Sikonja M,Kononenko I.Theoretical and empirical analysis of Relief F and RRelief F.Mach Lear J,2003,53:23-69.
  • 9Tsai CT,Lai LP,Lin JL,et al.Renin-angiotensin system gene polymorphisms and atrial fibrillation.Circulation,2004,109:1640-1646.
  • 10Hahn LW,Moore JH.Ideal discrimination of discrete clinical endpoints using multilocus genotypes.In Silico Biol,2004,4:183-194.

共引文献30

同被引文献54

  • 1赵爱玲,赵靖平,薛志敏,陈晋东,陈晓岗,刘哲宁,李乐华.多巴胺D_4受体基因与精神分裂症质量性状和数量性状的关联分析[J].中华精神科杂志,2005,38(1):3-6. 被引量：6
  • 2胡一文,王高华,王惠玲,刘忠纯,唐记华.中国汉族健康人群多巴胺D1受体-48A/G基因多态性与精神分裂症的相关性[J].中国临床康复,2005,9(24):118-119. 被引量：3
  • 3唐迅,李娜,胡永华.应用多因子降维法分析基因-基因交互作用[J].中华流行病学杂志,2006,27(5):437-441. 被引量：30
  • 4Steinberg EM, Rubinow DR, Bartko JJ, et al. A cross-sectional evaluation of perimenopausal depression[J]. J Clin Psychiatry, 2008, 69(6) : 973 -980.
  • 5Cohen LS, Soares CN, Vitonis AF, et al. Risk for new onset of depression during the menopausal transition: the Harvard study of moods and cycles[ J]. Arch Gen Psychiatry, 2006, 63(4) : 385 - 390.
  • 6OsterIund MK, Hurd YL. Estrogen receptors in the human forebrainand the relation to neuropsychiatric disorders [ J ]. Prog Neurobiol, 2001, 64(3): 251 -267.
  • 7Nederhof E, Bouma EM, Oldehinkel A J, et al. Interaction between childhood adversity, brain-derived neurotrophic factor val/met and serotonin transporter promoter polymorphism on depression: the TRAILS study[ J]. Biol Psychiatry, 2010, 68 (2): 209- 212.
  • 8Lesch KP, Bengel D, Heils A, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region[J]. Science, 1996, 274(5292): 1527-1531.
  • 9Ogilvie AD, Battersby S, Bubb V J, et al. Polymorphism in seroto- nin transporter gene associated with susceptibility to major depres- sion[J]. Lancet, 1996, 347(9003): 731 -733.
  • 10沈渔邮.精神病学.第4版[M].北京:人民卫生出版社,2005:432-433.

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中华医学杂志
2010年 第43期

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