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血液透析患者促红细胞生成素抵抗的相关性研究 被引量：2

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摘要 贫血是当前造成终末期肾脏病（end—stage renal disease，ESRD）患者病情加重和死亡的主要原因之一。基因重组人促红细胞生成素（recombinant human erythropoietin，rHuEPO）的合理应用，使ESRD患者的贫血得到纠正，降低了其住院率和死亡率。但临床上仍有约5％～10％的ESRD患者需要使用较大剂量的rHuEPO才能使红细胞压积（hematocrit，Hct）和血红蛋白（hemoglobin，Hb）达到靶目标水平，
作者 王尊松 崔美玉 张磊 许冬梅
机构地区 山东大学附属千佛山医院肾内科 山东省胸科医院内三科
出处 《山东大学学报（医学版）》 CAS 北大核心 2010年第11期129-132,共4页 Journal of Shandong University:Health Sciences
关键词 血液透析 促红细胞生成素 促红细胞生成素抵抗
分类号 R459.5 [医药卫生—治疗学]
  • 相关文献

参考文献14

  • 1Lopez-Gomez J M, Portoles J M, Aljama P. Factors that condition the response to erythropoietin in patients on hemodialysis and their relation to mortality [ J ]. Kidney Int, 2008,12( Suppl 111 ) :75-81.
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同被引文献30

  • 1张伟明,钱家麒.上海市透析登记及其结果分析[J].中国血液净化,2012,11(5):233-236. 被引量：83
  • 2钱家麒.透析患者高血压的发生机制[J].中国血液净化,2007,6(1):3-4. 被引量：14
  • 3吴凡,喻陆,张智敏,石海滨.血液透析对终末期肾衰患者血清中血红素氧化酶-1及炎症因子的影响[J].南方医科大学学报,2007,27(3):368-370. 被引量：5
  • 4Zhang L, Wang F, Wang HY,et al.Prevalence of chronic kidney dis-ease in china:a cross-sectional survey [ J].Lancet, 2012,379(9818):815-822.
  • 5Chen N, Wang W, Huang YD, et al.Community-based study onCKD subjects and the associated risk factors [ J].Nephrol DialTransplant,2009,24(7):2117-2123.
  • 6Farmer CK, Goldsmith DJ, Cox J,et al.An investigation of the effectof advancing uraemia, renal replacement therapy and renal trans-plantation on blood pressure diurnal variability [ J].Nephrol DialTransplant,1997,12(11) :2301-2307.
  • 7Agarwal R, Alborzi P,Satyan S.Dry-Weight Reduction in Hyper-tensive Hemodialysisi Patients ( DRIP): a randomized,controlledtrial[ J].Hypertension,2009 ,53(3):500-507.
  • 8Agarwal R,Light RP.Arterial stiffness and interdialytic weightgaininfluence ambulatory blood pressure patterns in hemodialysispatients[ J].Am J Physiol Renal Physiol,2008 ,294 (2): F303-F308.
  • 9Makayama M,Kawaquchi Y,Multicenter Survey on Hydration Sta-tus and Control of Blood Pressure in Japanese CAPD Patients[ J].Perit Dial Int,2002 ,22( 3):411-414.
  • 10Menon MK, Maimark DM, Bargman JM.Long-term blood pressurecontrol in a cohort of peritoneal dialysis patients and its associationwith residual renal function[ J].Nephrol Dial Transplant,2001,16(11):2207-2213.

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山东大学学报（医学版）
2010年 第11期

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