普罗布考联合阿托伐他汀治疗不稳定型心绞痛疗效观察

Efficacy of probucol combined with atorvastatin in treatment of coronary heart disease with unstable angina

目的观察普罗布考联合阿托伐他汀治疗不稳定型心绞痛的临床疗效及安全性。方法100铡不稳定型心绞痛患者按随机原则分为A组和B组各50组，在常规治疗的基础上，A组采用普罗布考治疗，B组采用普罗布考联合阿托伐他汀治疗，观察两组治疗前后疗效、平板运动心电图试验、血脂及氧化指标变化情况。结果B组总有效率90．0％，明显高于A组64．0％（x2=3．841，P〈0．05）；B组治疗后心电图改善总有效率为74．0％，明显高于A组42．0％（x2=3．981，P〈0．05）；两组治疗后平板运动心电图试验阳性率明显低于治疗前（x2=3．841、3．791，均P〈0．05）；A、B组治疗后心绞痛发作[（1．6±0．8）次、（1．0±0．5）次]明显低于治疗前[（4．3±1．9）次、（4．6±2．8）次]（x2=7．584、7．984，均P〈0．01）。结论普罗布考联合阿托伐他汀治疗不稳定型心绞痛可明显减少心绞痛发作、改善患者临床症状。

Objective To compare the influence of blood lipids and angina pectoris using combination therapy in coronary heart diseases （CHD） with unstable angina. Methods 100 patients were randomly divided into the probucol group（ A group） 50 cases and prohucol combined with atorvastatin treatment group（ B group） 50 cases ,The treadmill exercise ECG test,lipid and oxidation before and after treatment in two groups were observed. Results The total effective rate was 90. 0% in group B significantly higher than 64. 0% in group A （ x2 = 3. 841, P 〈 0. 05 ） ; The total effective rate of ECG was 74.0% in group B after treatment which was significantly higher than the 42. 0% in group A （x2 = 3.981, P 〈 0. 05 ） ;Treadmill exercise ECG test positive 82. 0%, 84. 0% in two group before treatment, significantly higher than that 48. 0% ,24. 0% in two group after treatment, （ X2 =3. 841,3.791 ,all P 〈0. 05） ;Angina pectoris in A,B group after treatment[ （ 1.6 ± 0. 8） times,（ 1.0 ±0.5） times] were significantly lower than[ （4. 3 ± 1.9） times、（4.6 ±2. 8） times]before treatment（x2 =7.584,7.984,all P 〈0.01）. Conclusion Probucol was a safe and effective drug for treating hypolipidemic and reducing angina attack. Its combination with atorvastatin was safe, and the efficacy is more visible.