高血压患者糖代谢异常与高敏C反应蛋白的关系

Association of hs-CRP with abnormality of glucose metabolism in patients with essential hypertension

目的探讨原发性高血压患者糖代谢异常与高敏C反应蛋白（hs—CRP）的关系。方法120例原发性高血压患者，根据空腹血糖（FPG）和糖耐量试验（OGTT）结果分为糖耐量正常组（NGT组）、糖耐量异常组（IGT组）、糖尿病组（DM组）。用胶乳免疫增强比浊法测定三组患者血清hs-CRP。结果NGT组、IGT组及DM组hs—CRP水平逐渐升高，三组间差异有统计学意义（P〈0．05），hs—CRP与收缩压、舒张压、餐后2小时血糖、FPG均呈正相关（r=0．48、0．37、0．46、0．31，均P〈0．05）。结论原发性高血压患者并发不同程度糖代谢异常，其严重程度与血清hs—CRP有关。

Objective To investigate the association of high-sensitivity C-reactive protein（hs-CRP） with the abnormality of glucose metabolism in patients with essential hypertension. Methods Based on the level of fast plasma glucose（FPG） and 2-hours-plasma glucose （2hPG）, 120 patients with essential hypertension were divided into 3 groups：Normal glucose tolerance group（NGT） ,impaired glucose tolerance group（IGT）and diabetes mellitas group （DM）. The hs-CRP was measured. Results The level of hs-CRP gradually increased from NGT to DM groups（ P 〈 0. 05 ）. The level of hs-CRP was positively correlated with SBP,DBP,2hPG and FPG in patients with essential hypertension（ r = 0. 48,0. 37,0. 46,0. 31 ,P 〈 0. 05 ）. Conclusion The abnormality of glucose metabolism in patients with essential hypertension was related with hs-CRP.