奎硫平与利培酮治疗女性首发精神分裂症疗效比较

Contrast study of quetiapine and risperidone in female first-episode schizophrenia

目的比较利培酮与奎硫平治疗女性首发精神分裂症的疗效和不良反应。方法将80例符合CCMD一3诊断标准的精神分裂症按数字表法随机分为两组（奎硫平组和利培酮组各40例），分别给予奎硫平（300—750mg／d）和利培酮（2～5mg／d）治疗8周。用阳性与阴性症状量表评定疗效，并观察两组不良反应发生情况。结果两组治疗2、4、8周阳性与阴性症状量表评分比较差异均无统计学意义（均P〉0．05），奎硫平组和利培酮组治疗临床有效率分别为90．O％和87．5％，差异无统计学意义（P〉0．05），利培酮组发生震颤、肌强直、静坐不能、月经改变及泌乳等不良反应发生率显著高于奎硫平组（均P〈0．05）。结论奎硫平与利培酮治疗女性首发精神分裂症的临床疗效相当，但奎硫平不良反应小。

Objective To investigate the efficacy and adverse reaction of quetiapine compared to risperidone in female first-episode schizophrenia. Methods Eighty cases met the CCMD-3 criteria for schizophrenia were divided into two groups with random numbers table method, treated with quetiapine （ 300 ~ 750mg/d ） and risperidone （ 2 - 5mg/d） respectively for 8 weeks. The efficacy was measured with the positive and negative symptoms scale（ PANSS）, and the side effects were observed. Results The difference between two groups in 2-weekend, 4-weekend and 8- weekend PANSS had no statistical meaning（ all P 〉 0. 05 ）. The efficient rate of chnial treatment of quctiapine and ris- peridone groups were 90% and 87. 5% respectively,The difference had no statistical meaning（ P 〉 0. 05 ）. Risperidone group had higher incidence rate than quetiapine group in adverse reaction such as tremor, muscle rigidity, akathisia,emmenia change and lactation etc. Conclusion Quetiapine haa equivalent clinial effect with risperidone in female first-episode schizophrenia, and had less adverse reaction.