摘要
目的 探讨急性冠脉综合征（acute coronary syndrome, ACS）患者外周血糖化白蛋白（glycated albumin, GA）、单核/巨噬细胞趋化蛋白1（monocyte chemoattractant protein-1, MCP-1）和超敏C-反应蛋白（high-sensitivity C reactive protein, hs-CRP）水平的变化.方法 使用硝基四氮唑兰（NBT）显色法和酶联免疫吸附法分别测定96例急性冠脉综合征患者（急性冠脉综合征组,ACS组）,67例稳定型心绞痛患者（稳定型心绞痛组,SAP组）及53例胸痛、胸闷等症状予以冠脉造影正常的患者（对照组）血中GA、MCP-1和hs-CRP水平的变化.结果 外周血GA、MCP-1和hs-CRP水平在ACS患者明显高于SAP及对照组（P〈0.01）.ACS组外周血GA和MCP-1水平呈明显相关性（r=0.501,P〈0.01）.结论 ACS患者的GA、MCP-1和hs-CRP水平明显升高,GA是ACS预测的一个重要指标.
Objective To explore the correlation of glycated albumin （GA）, monocyte chemoattractant protein - 1 （ MCP - 1 ） and high - sensitivity C - reactive protein （ hs - CRP） in the peripheral blood of patients with acute coronary syndrome （ACS）. Methods The peripheral concentrations of GA, MCP - 1 and hs - CRP were measured in ninety - six patients with ACS （ ACS group）, sixty - seven patients with stable angina pectoris （ SAP group） and fifty - tbree patients as control subjects （ control group） by nitro blue tetrazolium reduction test （NBT） and enzyme - linked immunosorbent assay （ELISA）. Results GA, MCP - 1 and hs - CRP levels were significantly higher in ACS group than in SAP group and the controls （ P 〈 0. 01 ） ; GA level was positively correlated with MCP-1 level in ACS patients （r=0.501, P〈0.01）. Conclusion The levels ofGA, MCP-1 and hs - CRP were significantly increased in peripheral blood of patients with acute coronary syndrome. GA can be used to predict ACS.
出处
《中国急救医学》
CAS
CSCD
北大核心
2010年第11期994-997,共4页
Chinese Journal of Critical Care Medicine
基金
基金项目：江苏省卫生厅开放课题（No.WK0510）
