舒芬太尼联合氟比洛芬酯预防全麻苏醒期躁动

Sufentanil combined with flurbiprofen for preventing anesthesia agitation

目的:探讨术中应用舒芬太尼联合氟比洛芬酯预防全麻苏醒期躁动的效果。方法:选择ASAⅠ～Ⅱ级全身麻醉下进行胆囊切除术患者90例,随机分为3组,各30例。Ⅰ组给予舒芬太尼0.1μg·kg-1;Ⅱ组给予舒芬太尼0.15μg·kg-1;Ⅲ组给予氟比洛芬酯1mg·kg-1,舒芬太尼0.1μg·kg-1。在手术结束前20min静脉给药,观察比较苏醒期三组患者的躁动发生情况、疼痛评分及不良反应(恶心、呕吐等)。结果:Ⅱ组和Ⅲ组患者躁动发生率和疼痛评分均低于Ⅰ组(P<0.05),Ⅱ组和Ⅲ组间差异无显著性(P>0.05)。Ⅲ组不良反应发生率小于Ⅰ组和Ⅱ组(P<0.05)。结论:术中应用舒芬太尼联合氟比洛芬酯对预防全麻苏醒期躁动具有良好的效果,并能降低不良反应发生率。

Objective： Investigate the effect of sufentanil combined flurbiprofen prevention of anesthesia gitation. Methods： Select ASA Ⅰ - Ⅱ grade under general anesthesia, 90 patients with cholecystectomy, were randomly divided into 3 groups. Ⅰ group received sufentanil 0.1μgokg^-1; Ⅱ group received sufentanil 0.15 μgokg^-1; Ⅲ were given flurbiprofen 1 mg o kg^-1 and sufentanil 0.1 μgokg^-1. 20 min before the end of surgery they were given by vein. Observe and compare the emergence of three groups of patients the occurrence of agitation, pain score and side effects （nausea, vomiting, etc.）. Results： In Ⅱ and Ⅲ group the incidence of agitation and pain scores were lower than in group Ⅰ （P 〈0.05）. In Ⅱ and Ⅲ there was no significant difference （P〉 0.05）. In Ⅲ adverse reaction rate was less than in Ⅰ and Ⅱ （P 〈0. 05）. Conclusion： Intraoperative sufentanil combined flurbiprofen in preventing of anesthesia agitation has a good effect, and can reduce the incidence of adverse reactions.