肺炎支原体肺炎患儿免疫功能变化及匹多莫德对其治疗作用

Therapeutic Effect of Pidotimod on Mycoplasma Pneumoniae Pneumonia in Children and Changes of Their Immune Function

目的探讨肺炎支原体肺炎（MPP）患儿免疫功能变化及匹多莫德对其治疗作用。方法应用流式细胞仪检测2005年3月-2006年12月首都医科大学附属北京友谊医院儿科收治的35例MPP患儿外周血淋巴细胞亚群,另取9例健康儿童作为健康对照组。MPP患儿随机分为匹多莫德治疗组和一般治疗组。匹多莫德治疗组静脉滴注阿奇霉素（10 mg.kg-1.d-1）3~5 d,同时口服匹多莫德（每次400 mg）;一般治疗组仅静脉滴注阿奇霉素,剂量和疗程与匹多莫德治疗组相同。比较MPP患儿与健康儿童外周血淋巴细胞亚群的变化及匹多莫德治疗组与一般治疗组治疗后外周血淋巴细胞亚群的变化。应用SPSS 11.2软件对检测结果进行分析。结果 MPP患儿CD4＋及CD4＋/CD8＋比值均低于健康对照组儿童（Pa〈0.05）,CD19＋水平高于健康对照组儿童（P〈0.05）。匹多莫德治疗组CD4＋、CD4＋/CD8＋比值较一般治疗组均显著升高（Pa〈0.05）。结论 MPP患儿存在T淋巴细胞免疫功能低下和B淋巴细胞异常活化,匹多莫德可提高T细胞数量、增强CD4＋辅助性T细胞功能,有助于MPP的恢复。

Objective To explore the changes of immune function in children with mycoplasma pneumoniae pneumonia（MPP） and the-rapeutic effects of pidotimod.Methods T-lymphocyte subsets of 35 children with MPP in Department of Pediatrics of Beijing Friendship Hospital Affiliated to Capital Medical University from Mar.2005 to Dec.2006 were detected by flow cytometry,meanwhile 9 cases of healthy children as healthy control group.Children with MPP were divided to 2 groups：pidotimod therapy group and general therapy group.The children in pidotimod therapy group treated with azithromycin intravenous injection（10 mg·kg-1·d-1） and oral pidotimod.The general therapy group only treated with axithromycin intravenous injection.The therapy time were 3-5 days.The changes of T-lymphocyte subsets between MPP group and healthy control group,pidotimod therapy group and general therapy group were compared.SPSS 11.2 software was used to analyze the data.Results Compared with healthy control group,the levels of CD4＋ and CD4＋/CD8＋ of children in MPP group were decreased（Pa0.05）,levels of CD19＋ increased（P0.05）.Compared with general therapy group,levels of CD4＋ and CD4＋/CD8＋ in pidotimod therapy group increased（Pa0.05）.Conclusions T-lymphocyte subsets decreased and B-lymphocyte subsets increased in children with MPP.Pidotimod can up-regulate levels of CD4＋,amd improve pneumoniae recovery.