期刊文献+

抗肝纤维化药物的现状和展望 被引量:2

原文传递
导出
摘要 肝纤维化是肝脏对慢性损伤的一种修复反应,是慢性肝病共有的病理改变。肝纤维化的常见病因有病毒性肝炎、慢性酒精中毒、脂肪肝、血吸虫、肝脏淤血、淤胆、自身免疫、遗传和代谢性疾病、化学毒物或药物等,其特征是以胶原为主的细胞外基质(ECM)在肝内过多沉积。肝纤维化属可逆病变,其治疗主要是在有效去除病因的基础上,针对不同环节,采取相应措施,
作者 钟巍 谢渭芬
出处 《临床内科杂志》 CAS 2010年第11期729-732,共4页 Journal of Clinical Internal Medicine
  • 相关文献

参考文献29

  • 1Moreno MG,Muriel P.Remission of liver fibrosis by interferon-alpha 2b.Biochem Pharmacol,1995,50:515-520.
  • 2Hung KS,Lee TH,Chou W Y,et al.Interleukin-10 gene therapy reverses thioacetamide-induced liver fibrosis in mice.Bioebem Bioph Res Co,2005,336:324-331.
  • 3Stadlbauer V,Mookerjee RP,Hodges S,et al.Effect of probiotic treatment on deranged neutrophil function and cytokine responses in patients with compensated alcoholic cirrhosis.J Hepatol,2008,48:945-951.
  • 4Rosenbloom J,Castro SV,Jimenez SA.Narrative review:fibrotic diseases:cellular and molecular mechanisms and novel therapies.Ann Intern Med,2010,152:159-166.
  • 5Beham-Schmid C,Apfelbeck U,Sill H,et al.Treatment of chronic myelogenous leukemia with the tyrosine kinase inhibitor STI571 results in marked regression of bone marrow fibrosis.Blood,2002,99:381-383.
  • 6Yoshiji H,Noguchi R,Kuriyama S,et al.Imatinib mesylate(STI-571)attenuates liver fibrosis development in rats.Am J Physiol Gastrointest Liver Physiol,2005,288:G907-913.
  • 7Chen SW,Chen YX,Xie WF,et al.Targeted inhibition of platelet-derived growth factor receptor-beta subunit in hepatic stellate cells ameliorates hepatic fibrosis in rats.Gene Ther,2008,15:1424-1435.
  • 8Lebrec D,Thabut D,Oberti F,et al.Pentoxifylline does not decrease short-term mortality but does reduce complications in patients with advanced cirrhosis.Gastroenterology,2010,138:1755-1762.
  • 9Zhong W,Shen WF,Xie WF,et al.Inhibition of extracellular signalregulated kinase 1 by adenovirus mediated small interfering RNA attenuates hepatic fibrosis in rats.Hepatology,2009,50:1524-1536.
  • 10KJ Wohlschlaeger J,Lang H,Sotiropoulos GC,et al.Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection.J Hepatol,2008,48:83-90.

同被引文献39

引证文献2

二级引证文献3

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部