拉西地平合用阿托伐他汀钙对高血压颈动脉粥样硬化及血管内皮功能的影响

Effects of combined use of lacidipine and atorvastatin on carotid artherosclerosis and vascular endothelium in essential hypertension patients

目的:观察拉西地平合用阿托伐他汀钙的降压作用及对高血压患者颈动脉内膜-中膜厚度(IMT)及血管内皮功能的影响。方法:选择144例高血压伴颈动脉粥样硬化的患者,随机分为2组。实验组72例,服用拉西地平4～8mg.d-1,阿托伐他汀钙10mg,每晚1次;对照组72例,服用拉西地平4～8mg·d-1,疗程12个月。于治疗前后用彩色多普勒超声检测颈动脉内膜-中层厚度,肱动脉内皮依赖性舒张功能,监测血压、血脂变化。结果:实验组治疗后血压下降较对照组显著,实验组治疗后颈动脉IMT较对照组显著减小(P<0.05),肱动脉内皮依赖性舒张功能显著改善(P<0.05)。结论:拉西地平降压疗效显著,联合阿托伐他汀钙可以明显减轻颈动脉粥样硬化的病变,可作为高血压病并颈动脉粥样硬化的常规用药。

OBJECTIVE To study the effects of combined use of lacidipine and atorvastatin on blood pressure, intima-media thickness （IMT） and vascular endothelium. METHODS 144 patients, with essential hypertension and carotid atherosclerosis, were divided randomly into 2 groups. 72 patients of test group were treated with lacidipine 4- 8 mg·d^-1 and atorvastatin 10mg every night while lacidipine 4- 8 mg·d^-1 for 72 patients of control group for 12 months. Intima-media thickness of carotid and brachial artery endothelium-dependent diastolic function were tested by color Doppler ultrasound before and after the therapy, the blood pressure and blood lipid were also monitored. RESULTS After the therapy, there were significant differences between test group and control group in blood pressure, IMT and brachial artery endothelium-dependent diastolic function. CONCLUSION Lacidipine could be the normal medication of carotid atherosclerosis for it can lower blood pressure greatly and improve atherosclerosis while combination with atorvastatin.