参芪扶正注射液对脑肿瘤术后免疫功能影响的临床研究

Effect of Shen Qi Fuzheng Injection on Immune Function of Postoperative Brain Tumor Patients

目的:观察参芪扶正注射液对脑肿瘤术后免疫功能的影响。方法:将观察病例分成2组各40例,对照组在脑肿瘤术后予常规对症、支持治疗,治疗组在对照组治疗的基础上加用参芪扶正注射液静脉滴注。观察2组治疗前后的中医证候,进行外周血象、T淋巴细胞亚群(CD3+、CD4+、CD8+)等相关指标的检测。结果:2组术后中医证候显著改善率比较,差异有显著性意义(P<0.05)。治疗后治疗组血白细胞计数(WBC)、血红蛋白(Hb)、血小板计数(BPC)分别与对照组比较,差异均有显著性意义(P<0.05)。2组中良性肿瘤患者手术前后T淋巴细胞亚群、2组中恶性肿瘤患者手术前后T淋巴细胞亚群、治疗组良性肿瘤和恶性肿瘤患者手术前后T淋巴细胞亚群等分别比较,差异有显著性或非常显著性意义(P<0.05,P<0.01)。结论:参芪扶正注射液可明显改善脑肿瘤术后患者的临床证候、外周血象下降情况及免疫功能。

Objective:To observe the effect of Shen Qi Fuzheng Injection(SQFI) on immune function of postoperative brain tumor patients.Methods:Eighty postoperative brain tumor patients were randomized into 2 groups.The control group was given routine symptomatic and supportive treatment,and the treatment group was given intravenous drip of SQFI on the basis of routine symptomatic and supportive treatment.The changes of Chinese syndromes,peripheral blood count,and T lymphocyte subsets(CD3+,CD4+ and CD8+) were observed before and after treatment.Results:The differences of the improvement of postoperative Chinese syndromes were significant between the two groups(P<0.05).White blood cell(WBC) count,hemoglobin level and platelet count in the treatment group differed from those in the control group after treatment(P<0.05).The differences of T lymphocyte subsets were significant in the benign tumor patients of the two groups before and after treatment and in the malignant tumor patients of the two groups before and after treatment,and were also significant between the benign tumor patients and the malignant tumor patients in the treatment group before and after treatment(P<0.05 or P<0.01).Conclusion:SQFI can improve the Chinese syndromes,peripheral blood count and immune function of postoperative brain tumor patients.