蜂王信息素的改进合成

The Improved Synthesis of Queen Bee Pheromones

早在５０年代，Ｂｕｔｌｅｒ等［１］发现蜂王的上颚腺能分泌一种影响工蜂活动的物质，并提出了蜂群是靠蜂王分泌的该种化学物质传递各种个体间的信息的论断，Ｂａｒｂｉｅｒ等［２］测定其结构为９－氧代－２Ｅ－癸烯酸１（蜂王物质），并首次进行了人工合成．随后发现另...

In this paper, we described the synthesis of the main bioactive components of queen bee pheromones, queen substance 9\|oxo\|2\%E\%\|decenoic acid ( 1 ) and stink\|odour inhibitor 9\|hydroxy\|2\%E\%\|decenoic acid ( 2 ) from natural oleic acid. The key intermediate 9\|heptadecene\|2\|one ( 5Z]) was obtained by PdCl\-2(PPh\-3)\-2 catalytic decarboxylation of oleic acid and followed by Wacker oxidation. The synthesis of the trace components, 4\|hydroxy\|3\|methoxyphenylethanol ( 3 ), is also reported.