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紫杉醇或培美曲塞联合顺铂治疗晚期非小细胞肺癌的疗效观察 被引量：8

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摘要 目的比较紫杉醇或培美曲塞联合顺铂治疗晚期非小细胞肺癌(NSCLC)的临床疗效及毒副作用。方法将33例晚期NSCLC随机分为紫杉醇加顺铂组(TC)17例和培美曲塞加顺铂组(PC)16例。TC组紫杉醇85mg/m2,d1、8;顺铂75mg/m2,d1～3。PC组培美曲塞500mg/m2,d1;顺铂75mg/m2,d1～3,两组均为每21d一个周期重复。结果紫杉醇加顺铂组和培美曲塞加顺铂组有效率分别为52.9%和50.0%,两组之间有效率无统计学意义(P>0.05)。培美曲塞加顺铂组粒细胞减少的发生率小于紫杉醇加顺铂组。结论培美曲塞联合顺铂治疗晚期非小细胞肺癌的疗效与紫杉醇加顺铂的疗效相当,但副作用明显减少,可以作为临床一线治疗。
作者 郭依龙
机构地区 江苏省邳州市人民医院肿瘤科
出处 《齐齐哈尔医学院学报》 2010年第16期2549-2550,共2页 Journal of Qiqihar Medical University
关键词 非小细胞肺癌 化疗 紫杉醇 培美曲塞
分类号 R734.2 [医药卫生—肿瘤]
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参考文献13

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二级参考文献10

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齐齐哈尔医学院学报
2010年 第16期

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