重症肺炎支原体肺炎患儿血清C-反应蛋白和降钙素原的变化及其临床意义

Changes of Serum CRP and PCT in Children with Severe Mycoplasma Pneumoniae Pneumonia and Its Clinical Value

目的:探讨重症肺炎支原体肺炎(MPP)患儿血清C-反应蛋白(CRP)和降钙素原(PCT)的含量变化及其临床意义。方法:重症MPP住院患儿28例,在其发热3 d内、3～7 d以及热退后3 d分别检测患儿血清CRP和PCT的含量,同期住院的非感染性疾病患儿28例作为对照组。比较各组CRP和PCT水平。结果:重症MPP患儿在发热3 d内血清CRP和PCT仅轻度增高,而发热超过3 d后血清CRP和PCT含量较前明显增高,与对照组比较差异有统计学意义(P<0.05);当热退后,其含量也恢复正常,与对照组比较差异无统计学意义(P>0.05)。结论:动态监测MPP患儿血清CRP和PCT的变化,能帮助临床尽早准确地判断MPP患儿病情轻重,及时调整治疗方案,从而减少MPP严重并发症的发生。

OBJECTIVE： To probe into the change of serum ClIP and PCT in children with severe mycoplasma pneumoniae pneumonia （MPP） and its clinical significance. METHODS： 28 children with severe MPP were diagnosed and selected from May. 2009 to May. 2010. In the 3 days of fever, 3～7 days of fever and 3 days after reducing fever, the levels of serum CRP and PCT were measured. 28 children inpatients with non-infectious disease were involved in control group. The levels of CRP and PCT were compared. RESULTS： The levels of CRP and PCT in children with severe MPP increased slightly in 3 days of fever. The levels of CRP and PCT increased significantly in children with fever more than 3 days. There were significant differences between observation group and control group （P〈0.05）. The levels of CRP and PCT returned to normal after reducing fever （P〉0.05）. CONCLUSION： The levels of CRP and RCT which contribute to indentify the severity of MPP and to formulate therapeutic regimen should be monitored. The occurrence of severe complication of MPP can be reduced.