Convenient synthesis of chiral H_4-BINOL via direct hydrogenation of BINOL

chiral BINOL 的简单、高度有效的加氢被开发在 multigram 规模向 H4-BINOL 提供好产量(多达 78% 收益) 。一系列异构的催化剂在加氢被测试；最好的结果为 2 h 在 50 酒吧的 H2 压力下面在 EtOH 与 5% Pd/C 被获得。这个方法比另外的可得到的方法是为光学地纯的 H4-BINOL 的实际合成的一个更有用的方法。

A simple,highly effective hydrogenation of chiral BINOL to provide H_4-BINOL in multigram scale with good yield（up to 78% yield） was developed.A series of heterogeneous catalysts was tested in the hydrogenation;;the best result was obtained with 5%Pd/ C in EtOH under the H_2 pressure of 50 bar for 2 h.This method is a more useful method for practical synthesis of optically pure H4- BINOL than other available methods.