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母血中胎儿遗传物质与无创性产前诊断 被引量：2

Fetal genetic material in maternal plasma and non-invasive prenatal diagnosis
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摘要 经过10余年的发展,利用母体外周血中胎儿遗传物质进行无创性产前诊断的技术正逐步面向临床。本文综述了目前较为广泛被研究的母血中的胎儿遗传物质,着重阐述了使用无创的方法获得母血中胎儿遗传物质的方法及其优缺点。 After over 10 years of development, the use of fetal genetic material in maternal blood for noninvasive prenatal diagnostic technique gradually applied in clinical. This article aims to review the widely studied in the fetal genetic material in maternal peripheral blood at present, focusing on the advantages and disadvantages of using non-invasive method to obtain maternal peripheral blood in the fetal genetic material.
作者 费明钰 张毅 贾音 孙树汉
机构地区 第二军医大学基础医学部医学遗传学教研室
出处 《分子诊断与治疗杂志》 2010年第6期428-431,共4页 Journal of Molecular Diagnostics and Therapy
基金 国家科技支撑计划(2006BAI05A05) 国家自然科学基金(30901613) 上海市科委基础研究重大项目(08JC1405300) 上海市自然科学基金(09ZR1439100)
关键词 无创性产前诊断 母体外周血 胎儿有核红细胞 胎儿游离DNA 胎儿游离RNA Non-invasive prenatal diagnosis Maternal peripheral blood Fetus nucleated red cell Fetal free DNA Fetal free RNA
分类号 R714.5 [医药卫生—妇产科学]
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参考文献25

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同被引文献24

  • 1何蕴韶,夏邦顺.分子诊断与分子治疗是当代医学发展的必然[J].分子诊断与治疗杂志,2009,1(1):1-2. 被引量：2
  • 2吕建新.分子诊断学在检验医学中的应用前景[J].中华检验医学杂志,2005,28(2):137-139. 被引量：39
  • 3田晶,王峰,薛金凤,赵霏,钟梅,宋柳江,谭孟群.2型重组腺相关病毒介导的β-地中海贫血基因治疗实验[J].上海交通大学学报（医学版）,2011,31(1):9-14. 被引量：6
  • 4李翠莲,杨跃煌,代宏剑.应用PCR结合反向斑点杂交技术检测β-地中海贫血[J].中国小儿血液与肿瘤杂志,2007,12(1):9-12. 被引量：15
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  • 8Wataganara T,Chen AY, LeShane ES, et al. Cell free fetal DNA levels in maternal plasma after elective first-trimester termination of pregnancy[J]. Fertil Steril, 2004,81 (3) : 638.
  • 9Dennis Lo YM, Chiu RW. Prenatal diagnosis: progress through plasma nucleic acids[J]. Nat Rev Genet, 2007,8(1): 71.
  • 10Lo YM. Recent developments in fetal nucleic acids in maternal plasmg: implications to noninvasive prenatal fetal blood group genotyping[J]. Transfus Clin Biol, 2006,13 (1-2) : 50.

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分子诊断与治疗杂志
2010年 第6期

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