3.0 T MRI-SWI和FAIR技术对急性百草枯中毒中枢神经系统损害的研究

Study on Central Nervous System Damage of Acute Paraquat Poisoning by 3.0T MRI-SWI and FAIR Perfusion Techniques

目的 利用MRI-磁敏感加权成像(SWI)和流动敏感交互式反转恢复(FAIR)技术探索急性百草枯(PQ)中毒的中枢神经系统毒性。资料与方法 36例急性PQ中毒患者及其年龄、性别、职业相匹配的对照组36名进入本实验,搜集必要临床资料,行MRIT1-液体衰减反转恢复(FLAIR)、快速恢复快速自旋回波(FRFSE)-T2WI、重度T2*加权成像(ESWAN)-SWI和FAIR检查。比较两组不同脑区相对脑血流量(rCBF)的差异及其与血毒物浓度的关系。结果 SWI未发现异常出血灶。中毒患者中脑及额叶的rCBF低于对照组,差异有统计学意义,下降绝对值与血毒物浓度呈弱相关。不同脑区的rCBF值有明显差异,海马区血供较丰富。结论 急性PQ中毒可能影响了某些脑区的微循环(比如中脑),从而造成特异性损害。

Objective To explore the central nervous system damage of acute paraquat poisoning by 3.0T MRI-SWI and FAIR Perfusion techniques.Materials and Methods Thirty-six acute paraquat poisoning patients and 36 matched controls were enrolled into the study.After collecting the necessary clinical data,all the subjects performed MRI scans including T1flair,FRFSE-T2WI,ESWAN-SWI and FAIR sequences.The rCBF（relative cerebral blood flow）of difference brain areas between or within groups were compared,and the relationships between the rCBF changes and the blood poison concentration were analysed.Results No hemorrhage was seen on SWI.rCBF was significant decreased at frontal lobe and midbrain.The absolute value of decline had correlation with blood poison concentration.Difference of rCBF was showed between different brain areas within groups,and relatively higher rCBF was found athippocampus.Conclu-sion Acute paraquat poisoning may affect microcirculation of some brain areas,such as midbrain,and thus cause specific damages.