阴茎恶性黑色素瘤诊治分析

Analysis of diagnosis and treatment of malignant melanoma of penis

目的探讨阴茎恶性黑色素瘤的诊断和治疗方法。方法回顾性分析4例阴茎恶性黑色素瘤患者的临床病理学特征、诊治过程及预后情况。结果 4例患者经病理学检查确诊为阴茎恶性黑色素瘤;临床分期Ⅰ期1例(T1N0M0),Ⅲ期3例(T3N2M0、T3N2M0和T4N3M0各1例);4例患者均接受手术治疗,3例阴茎部分切除加双侧腹股沟淋巴结清扫术,1例阴茎全切加双侧腹股沟淋巴结清扫术;术后随访6～60个月,1例临床分期I期患者术后随访60个月肿瘤无复发;2例临床分期Ⅲ期患者术后2年内死亡。结论前期痣的长期存在可能是阴茎恶性黑色素瘤发生的危险因素,早期发现和及时手术对改善阴茎恶性黑色素瘤患者的预后至关重要。

Objective To discuss the methods of diagnosis and treatment of malignant melanoma of penis.Methods The clinicopathological characteristics,procedures of diagnosis and treatment,and prognosis of 4 cases of malignant melanoma of penis were retrospectively analysed.Results All the 4 cases were confirmed as malignant melanoma of penis by pathological examinations.One case was classified as stageⅠ （T1N0M0） and the other three cases stage Ⅲ （T3N2M0,T3N2M0 and T4N3M0,respectively）.Partial penectomy was performed in three cases and radical penectomy in the other one,and all were conducted bilateral inguinal lymphadenectomy.Patients were followed up for 6 to 60 months,and two died.Conclusion Preexisting nevi may be risk factors for development of malignant melanoma of penis,and early diagnosis and proper surgical therapy are of paramount importance in improving the prognosis.