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成血管血液干细胞特化形成相关基因的研究进展

Research advances of hemangioblast in regulation of specialization gene
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摘要 Previous research has confirmed that hematopoietic cells and endothelial cells originate in a common mesodermal precursor named as hemangioblast at specific time and locations during embryonic development. Hematopoietic cells and endothelial cells were originated gradually from hemangioblast by specialization, determination and differentiation step by step. The author reviews the origin, markers, commitment, and differentiation of hemangioblast, and presents some research evidence on the transcriptional factors and influencing genes for the specialization of hemangioblast. Further research on specialization genes of the hemangioblast will be critical for a better understanding of the events involved in hematopoietic and endothelial cell differentiation as well as for utilizing this cell population for clinical applications. Previous research has confirmed that hematopoietic cells and endothelial cells originate in a common mesodermal precursor named as hemangioblast at specific time and locations during embryonic development. Hematopoietic cells and endothelial cells were originated gradually from hemangioblast by specialization, determination and differentiation step by step. The author reviews the origin, markers, commitment, and differentiation of hemangioblast, and presents some research evidence on the transcriptional factors and influencing genes for the specialization of hemangioblast. Further research on specialization genes of the hemangioblast will be critical for a better understanding of the events involved in hematopoietic and endothelial cell differentiation as well as for utilizing this cell population for clinical applications.
作者 王跃嗣
机构地区 滨州医学院药学院细胞工程教研室
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2010年第11期2264-2269,共6页 Chinese Journal of Pathophysiology
基金 国家自然科学基金资助项目(No.30801353) 烟台市科技发展计划资助项目(No.2007153)
关键词 成血管血液干细胞 造血干细胞 基因表达调控 Hemangioblast Hematopoietic stem cells Gene expression regulation
分类号 R332.2 [医药卫生—人体生理学]
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参考文献24

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中国病理生理杂志
2010年 第11期

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