基于稳态的三维高分辨扩散加权序列核磁共振在帕金森病诊断中的应用

Application of three-dimensional high-resolution diffusion-weighted MRI based on steady state in diagnosis of Parkinson disease

目的:探讨基于稳态的三维高分辨扩散加权序列核磁共振在帕金森病诊断中的应用。方法:选择原发性帕金森病患者20例,正常对照组13例,行常规核磁共振序列及基于稳态的三维高分辨扩散加权序列扫描,获得双侧黑质、红核的标准化体积、各向异性比值、表观弥散系数,比较两组的差异,并研究其与年龄、病程、病情严重程度、震颤、强直、运动迟缓、姿势平衡障碍的相关性。结果:帕金森病组与对照组红核及黑质的标准化体积之间的差异无统计学意义,帕金森病组黑质的各向异性比值低于对照组(P<0.05),表观弥散系数低于对照组(P<0.01),帕金森病组黑质的各向异性比值与病程呈负相关,与年龄、病情严重度、震颤、强直、运动迟缓及姿势平衡障碍无相关性。结论:应用基于稳态的三维高分辨扩散加权序列核磁共振能够获得较高分辨率的黑质、红核影像,可协助帕金森病的诊断。

AIM： To explore the value of three-dimensional high-resolution diffusion-weighted magnetic resonance imaging （MRI） based on steady state in free precession technique （3D-DW-SSFP） at 3.0 T for diagnosis of Parkinson disease. METHODS： Twenty patients with idiopathic Parkinson disease （PD） and 13 controls were enrolled in this study. Standardization volume, fractional anisotropy （FA） and apparent diffusion coefficient （ADC） of substantia nigra and red nucleus in PD patients together with controls were obtained using regular MRI based on 3D-DW-SSFP at 3.0 T. The data of duration, age, clinical severity, tremor, rigidity, bradykinesia and posture stability between the PD patients and the controls were compared.RESULTS： No significant difference of the standardization volume of substantia nigra and red nucleus between PD patients and controls was observed. The FA and ADC values of the substantia nigra in PD patients were lower than those in controls （P〈0.05 and P〈0.01,respectively）, and FA value had inverse correlation with the duration of PD. The values of FA and ADC had no relationship with tremor, rigidity, bradykinesia and postural stability. CONCLUSION： 3D-DW-SSFP can be used for obtaining high-resolution MRI image of substantia nigra and red nucleus. It is helpful for the diagnosis of Parkinson disease.