原发性闭角型青光眼小梁细胞相关变化的研究进展

Advancement of correlative changes of trabecular cells in primary angle-closure glaucoma

原发性闭角型青光眼房角关闭致房水流出受阻,眼压升高。随着房角的关闭,小梁细胞在形态及生理功能上都会发生变化。有报道原发性闭角型青光眼经超声乳化联合房角分离术后,在一定时间内眼压会有不同程度的下降,说明房角重新开放后,小梁细胞也发生了相关变化,功能得到了不同程度的恢复。但其具体机制以及与房角关闭持续时间的关系等还需要进一步研究和探讨。

In primary angle-closure glaucoma, the iris is pushed or pulled up against the trabecular meshwork at the angle of the ocular anterior chamber. Aqueous humor is blocked and cannot drain out, thereby increasing the IOP. After the angle closes ,changes will happen to the trabecular cells morphologically and physiologically. Studies show that IOP will decrease for some degree after phacoemulsification plus intraocular lens implantation and combined with goniosynechialysis for primary angle-closure glaucoma.It is suggested that the function of trabecular cells can restore partially when the angle reopened. However its specific mechanism need further research and discussion.