妊娠高血压综合征眼底改变350例临床分析

Clinical analysis of the fundus changes of 350 cases with pregnancy induced hypertension syndrome

目的:探讨妊娠高血压综合征(pregnancy induced hypertension syndrome,PIHS)患者的血压、蛋白尿和水肿与眼底改变的关系。方法:回顾性分析眼底改变与PIHS的血压、蛋白尿、水肿的关系,眼底改变用直接眼底镜进行检查。结果:在350例患者中发现正常眼底112例(32.0%),视网膜病变238例(68.0%)。PIHS在妊娠高血压期、轻度子痫前期、重度子痫前期和子痫期其眼底改变的百分比分别为52.5%,60.0%,70.3%和100%,且PIHS越严重,眼底改变越严重,呈现正相关性,四组病例之间有显著差异(P<0.01)。结论:PIHS眼底改变与PIHS的血压高低程度相一致,而眼底改变越严重,蛋白尿、水肿的发生率越高,说明眼底改变是反映全身多系统器官受损的一项重要指标。

AIM：To investigate the relationship among blood pressure,proteinuria,edema and fundus changes of the patients with pregnancy hypertension syndrome（PIHS）. METHODS： We carried a retrospective analysis of the relationship among blood pressure,proteinuria,edema and fundus changes.The fundus was examined by the direct ophthalmoscope. RESULTS：Fundus was normal in 112 patients （32.0% ）and retinopathy was in 238 patients（68.0%）.In the four degrees of PIHS patieints （gestational hypertension group,slight pre-eclampsia group,severe pre-eclampsia group and eclampsia group）,the incident rates of fundus changes were 52.5%, 60.0%,70.3% and 100% respectively,and there was great significant difference among fourgroups. CONCLUSION： Fundus change is related to the elevation of blood pressure.Fundus changes are more serious,incidence of proteinuria and edema become more higher.So fundus change is an important sign to reflect lesion of organs.