口服α1受体激动剂治疗慢性前列腺炎合并勃起功能障碍24例报告

The Clinic Effect of Alpha-adrenoceptor（α1） agonist on Erectile Dysfunction resulted from Chronic prostatitis

目的：探讨口服α1肾上腺受体激动剂在后期治疗慢性前列腺炎合并的勃起功能障碍的可行性及初步疗效。方法：24例慢性前列腺炎合并勃起功能障碍的患者，年龄28～45岁，平均31．6岁；勃起功能障碍病程平均7月；IIEF-5问卷指数平均为14．5±3．96分；前期治疗前列腺炎1—3月后，以盐酸米多君2．5mg，bid；性交前一小时加服10mg，每周至少性生活一次，共治疗四周。治疗后，以IIEF-5问卷评价疗效。结果：治疗后，有效者（IIEF-5问卷指数为12—21分）为4例，显著疗效者（IIEF-5问卷指数为21～25分）为17例，无效者3例，总有效率为87．5％；IIEF-5问卷指数上升平均达20．36±5．38分，治疗前后差异有显著性意义。无严重副作用。结论：α1肾上腺受体激动剂（盐酸米多君）后期治疗慢性前列腺炎合并的勃起功能障碍疗效确切并肯定，也是安全可行的。可能是治疗勃起功能障碍可供选择的新方法之一。

Objective To evaluate the practicalityt and effect of Alphaadrenoceptor （α1） agonis （Midodrine Hydrochloride） on erectile dysfunction resulted from chronic prostatitis. Methods Total of 24 cases of erectile dysfunction resulted from chronic prostatitis with average aeg of 31.6, average symptoms＇ history of 7.5 months, average IIEF-5 score of 14,5 4- 3.96, underwent the therapy, intaking Midodrine Hydrochloride 2,5rag twice a day, plus 10mg about an hour ahead of sexual intercourse done once a week at least, for 4 weeks. The effect had been entirely assessed by IIEF-5. Results The whole effective rate of this series was 87.5%, with only 3 patients of no effect. The average score of IIEF-5 had risen to 20.36± 5.38 from previous 14.5±3.96. No side reaction occurred. Conclusions Alphaadrenoceptor （α1） agonist （Midodrine Hydrochloride） applied on erectlie dysfunction resulted from chronic prostatitis was practical, safe and simple. Its effect was positive. It maybe one choice of new therapies on erectlie dysfunction.