屈光不正性弱视患者多焦视网膜电图一阶反应P1波特征分析

Analysis of multifocal electroretinogram first-order kernel P1 wave in anisometropic amblyopia

目的 研究屈光参差性弱视患者mfERG一阶反应P1波特征,探讨mfERG在弱视诊断中的应用价值.方法 采用罗兰RETIscan型电生理仪检测一组（15例）屈光参差性弱视患者mfERG,选择一阶反应第一环P1波为指标,计算其平均振幅密度（nV·deg-2）及潜伏期（ms）,采用配对t检验比较弱视眼与对侧健眼的统计学差异.结果 弱视眼P1波平均振幅密度为（164.7±73.1）nV·deg-2,对侧健眼为（227.0±61.3）nV·deg-2,差异有统计学意义（t=2.554,P=0.016）;弱视眼P1波平均潜伏期为（30.3±4.3）ms,对侧健眼为（34.4±3.2）ms,差异有统计学意义（t=2.92,P=0.007）.结论 屈光参差性弱视患者弱视眼mtERG一阶反应第一环P1波有明显改变,提示弱视眼存在视网膜开-双极细胞功能及视觉信息传导异常,mfERG有可能用作弱视的诊断的客观指标.

Objective To investigate the features of the multifocal electroretinogram（mfERG） firstorder kernel P1 wave in anisometropic amblyopic eyes. Methods mfERG of fifteen anisometropic amblyopic eyes and their normal control eyes were recorded with ROLAND RETIscan visual evoked response system,the mean amplitude density and eclipse period of the P1 wave were analyzed and compared between the amblyopic and normal eyes with t-test. Results The P1 wave amplitude density of mfERG first-order kernel in amblyopic eyes （164.7±73.1） nV·deg-2 was significantly attenuated in the central region of the visual field as compared with that of the control eyes （227.0±61.3） nV·deg-2 （t=2.554,P=0.016）.The eclipse period of the amblyopic eyes（30.3 ±4.3）ms was shorter than that of the control eyes （34. 4 ±3.2）ms （ t = 2. 92, P = 0. 007 ）. Conclusions The significant change of the multifocal electmretinogram （mfERG） first-order kernel P1 wave may reflect the abnormality of the retinal on-bipolar cells function and the visual information transmission, whether the P1 wave could be used as an objective index of amblyopic eyes is a promising research topic.