OGFR mRNA在乳腺浸润性导管癌中的表达

Expression of OGFR mRNA in Invasive Ductal Carcinoma of Breast

目的探讨乳腺浸润性导管癌中OGFR mRNA的表达意义。方法采用逆转录-聚合酶链反应(RT-PCR)方法检测乳腺良性上皮增生、浸润性导管癌中OGFR mRNA的表达。结果 OGFR mRNA表达量在乳腺良性上皮增生组明显高于浸润性导管癌组(P<0.05);在浸润性导管癌中的表达与患者年龄、肿瘤体积、组织学分级、雌孕激素受体表达、c-erbB-2表达及淋巴结转移无关(P>0.05)。结论 OGFR mRNA表达减少可以作为乳腺浸润性导管癌的标志;OGFR在mRNA水平表达量减少,可能与乳腺癌的发生发展有关。

Objective To elucidate the features of OGFR mRNA expression in invasive ductal carcinoma of breast.Methods RT-PCR was used to detect the expression of OGFR mRNA in benign epithelial proliferation and invasive ductal carcinoma tissues of breast.Results The expressing quantity of OGFR mRNA was significantly higher in benign epithelial proliferation than that in invasive ductal carcinoma tissues（P〈0.01）.There was no significant difference between the expression of OGFR mRNA and patient＇s ages,volumes and grades of tumor,the expression of ER,PR,C-erbB-2 and lymphatic metastasis（P〈0.05）.Conclusion The reduced level of OGFR mRNA may serve as a marker of breast invasive ductal carcinoma.The subnormal levels of OGFR mRNA may contribute to the progression of breast carcinoma.