黛力新辅助治疗老年非糜烂性反流病合并心理障碍的临床研究

A clinical trial of auxiliary therapy with Deanxit in elderly patients of non-erosive reflux disease complicated with psychologic obstacle

目的观察黛力新辅助治疗合并心理障碍的老年非糜烂性胃食管反流病(NERD)的疗效。方法 47例合并心理障碍的老年NERD患者随机分为2组(治疗组26例,对照组21例),对照组予泮托拉唑(40mg,qd)和莫沙比利(5mg,tid);治疗组在对照组基础上加用黛力新(每天早上1粒),治疗4周后进行疗效比较。结果治疗组总有效率80.8%,对照组总有效率52.4%,两组比较具有显著性差异(χ2=4.30,P<0.05)。结论黛力新辅助泮托拉唑、莫沙比利治疗合并心理障碍老年NERD有良好疗效,值得推广运用。

Objective To observe the effect of auxiliary therapy with Deanxit in elderly patients of non-erosive reflux disease （NERD） complicated with psychologic obstacle. Methods A total of 47 NERD complicated with psychologic obstacle elderly patients were divided into treatment group （ n = 26） and control group （ n = 21） . All patients were given pantoprazole （ 40 mg,qd） and mosapride （ 5 mg,tid） . Patients in the treatment group were given the same therapy plus Deanxit （ one tablet every morning） . The clinical outcomes of two groups were compared after 4 weeks. Results The effective rate in treatment group was 80. 8% ,while that was 52. 4% in control group. There was significant difference between the two groups （ χ2 = 4. 30,P 0. 05） . Conclusion Auxiliary therapy with Deanxit can improve the clinical effect of elderly patients of NERD complicated with psychologic obstacle.