西甲硅油联合糜蛋白酶溶液作胃镜检查术前准备的临床观察

Clinical observation of applying solution of simethicone plus chymotrypsin before gastroscopy examination

目的分析西甲硅油联合糜蛋白酶溶液作为胃镜检查术前准备时,对胃镜疾病检出率的优势,为临床使用提供依据。方法将行胃镜检查的患者随机分成两组,研究组检查前20min予以西甲硅油联合糜蛋白酶溶液50mL,口服,检查前10min再服下10mL利多卡因胶浆;对照组仅口服利多卡因胶浆10mL,胃镜下观察视野清晰程度,记录胃镜检查时间、微小病灶发现率。并行部分胃部肿瘤病理回顾。结果西甲硅油联合糜蛋白酶溶液处理组与对照组比较,内镜下视野清晰程度明显增高(A+B级,98.5%vs45.6%,P<0.05)。检查时间缩短(P<0.05),微小病灶(红斑、糜烂、息肉样增生、出血点)检出率增高(P<0.05),并更易于提高早期胃部肿瘤的检出率。结论西甲硅油联合糜蛋白酶溶液可作为较好的胃镜检查前准备之一,提高疾病的诊断率。

Objective To evaluate the efficacy of the solution of simethicone plus chymotrypsin as preoperative preparation of gastroscopy examination. Methods Patients taken gastroscopy randomly divided into two groups. One hundred and ninety-five patients in treated group received the solution of simethicone plus chymotrypsin 50 mL orally and lidocaine hydrochloride mucilage 10 mL orally,195 patients in control group received lidocaine hydrochloride mucilage 10 mL orally before the gastroscopic examination. The lucidity extent,time of examination and positive detection rates of micro-lesion were investigated and recorded. Furthermore,retrospective analysis was taken for gastric tumor patients. Results The lucidity extent in treated group significantly increased,time of examination decreased,and positive detection rates of micro-lesion （ erythema,erosion,polyps and petechia） were improved compared with control group （ P 0. 05） . Conclusion The solution of simethicone plus chymotrypsin could be used for preoperative preparation for gastroscopy to improve the diagnostic rate of disease.