盐酸度洛西汀与加巴喷丁治疗糖尿病周围神经痛疗效对比

Comparison of Effects Between Duloxetine and Gabapentin in the Treatment of Diabetic Peripheral Neuropathic Pain

目的:探讨盐酸度洛西汀与加巴喷丁治疗糖尿病周围神经痛临床疗效。方法:纳入63例2型糖尿病合并糖尿病周围神经痛(DPNP)病例,随机为两组,分别使用盐酸度洛西汀肠溶胶囊(治疗组,n=31)与加巴喷丁胶囊(对照组,n=32),于治疗前和治疗后第1,2,4周进行疼痛视觉模拟评分(VAS)以及记录患者出现的不良反应。结果:与用药前VAS相比,盐酸度洛西汀组和加巴喷丁组患者用药后1,2,4周VAS均显著下降(P<0.01),两组同时间的VAS比较,差异无统计学意义(P>0.05),用药后两组同时间有效率的差异亦无统计学意义(P>0.05),加巴喷丁组不良反应的发生率高于盐酸度洛西汀组。结论:盐酸度洛西汀治疗糖尿病周围神经痛有效,不良反应发生明显少于加巴喷丁。

Objective：To study the clinical efficacy of duloxetine and gabapentin in treating diabetic peripheral neuropathic pain.Methods：Sxity-three patients with type 2diabetes with diabetic peripheral neuropathic pain were randomly allocated into two groups,group A（duloxetine,n=31）and group B（gabapentin,n =32）.Visual analogue scale（VAS）and adverse reactions were recorded before treatment and in 1,2,and 4weeks after treatment.Results：VAS in both groups were significantly decreased in 1,2,4weeks after treatment（all P0.01）.There was no significant difference in VAS at the same time and in clinical efficacy between the two groups.The ratio of adverse reactions in duloxetine group was significant lower than that in gabapentin group.Conclusion：Duloxetine is effective in the treatment of diabetic peripheral neuropathic pain,and adverse events were less than those of gabapentin.