Stathmin蛋白在大肠癌中的表达及临床意义

Expression of Stathmin in colorectal carcinoma and its clinical significance

目的:探讨Stathmin蛋白在大肠癌中的表达及其与肿瘤病理特征的关系。方法:采用免疫组织化学SP法检测56例大肠癌组织Stathmin蛋白的表达,同时选取16例大肠腺瘤组织作对照。结果:Stathmin蛋白在大肠癌中的阳性表达率为60.7%(34/56),明显高于大肠腺瘤组织的31.3%(5/16),P<0.05。Stathmin蛋白表达与肿瘤部位、大小、分化程度、Duke's临床分期及淋巴结转移均无明显相关,P>0.05。结论:Stathmin蛋白过表达与大肠癌的发生密切相关,但它不能作为判断大肠癌恶性程度的指标。

Objective：To explore the expression of Stathmin protein in colorectal carcinoma and its relation to clinicopathologic features.Methods：The Stathmin protein levels in 56 cases of colorectal carcinoma and 16 cases of colorectal adenoma were detected by immunohistochemistry method.Results：The positive rates of Stathmin in colorectal carcinoma（34/56,60.7%） significantly higher than those in colorectal adenoma（5/16,31.3%）,P 0.05.The positive expression of Stathmin was not associated with tumor size,location,differentiation,Duke＇s stage and lymphnode metastasis.Conclusion：Stathmin may play a role in the carcinogenesis of colorectal carcinoma,but it is not a good marker for evaluation of tumor biological features.