COX-2、VEGF和EGFR在胃癌中的表达和意义

Expression and significance of COX-2,VEGF and EGFR in gastric cancer

目的:探讨COX-2、VEGF和EGFR这三种与肿瘤血管生成相关的蛋白在胃癌中的表达及其与临床病理特征的关系。方法:选取140例胃癌标本,应用免疫组化S-P法检测COX-2、VEGF和EGFR的表达,并与临床参数进行比较分析。结果:COX-2、VEGF和EGFR在胃癌标本中的阳性表达率分别为49.29%(69/140)、47.86%(67/140)、45.71%(64/140)。三者表达与年龄、性别、部位、肿瘤大小、分化程度均无关。胃癌中COX-2和EGFR的表达与浸润深度、淋巴结转移、TNM分期显著相关(P<0.05)。VEGF表达与各种临床病理特征均无关(P>0.05)。VEGF与COX-2表达呈正相关(P<0.000)。结论:COX-2、EGFR与胃癌的浸润、转移及预后密切相关,可作为判断胃癌生物学行为和预后的重要参考指标。

Objective：To evaluate the expression of COX-2,VEGF and EGFR,the three main angiogenesis related proteins,and the relationship between expression and clinic pathologic parameters in patients with gastric cancer.Methods：The expressions of COX-2,VEGF and EGFR in 140 samples of gastric cancer tissues were analyzed with S-P immunohistochemistry,the results were compared with relevant clinical characteristics.Results：The positive rates of cytoplasmic expression of COX-2,VEGF and EGFR were 49.29%,48.86% and 45.71% respectively.Their expression was not correlated with sex,age,size,site of tumor and degree of differentiation（P 0.05）.The positive expression rates of COX-2 and EGFR were related to the depth of invasion,clinical stage and lymph node metastasis of gastric cancer patients（P 0.05）.There was no correlation between VEGF expression and clinical characteristics（P 0.05）.A positive correlation was found between expression of COX-2 and VEGF（r = 0.314,P = 0.000）.Conclusion：The expression of COX-2 and EGFR was closely related to invasion,metastasis and prognosis of gastric cancer,and they could be used to evaluate the biological behaviors and prognosis of gastric cancer.COX-2 may be accelerate angiogenesis by increasing VEGF expression and can predict prognosis of gastric cancer.