NF-кB与COX-2在胃癌及转移淋巴结中的表达研究

Expressions of NF-кB and COX-2 in gastric carcinoma and regional lymph node

目的:探讨NF-кB与COX-2在胃癌原发灶及淋巴结转移灶中的表达关系及临床意义。方法:采用免疫组织化学方法(S-P法)对胃癌原发灶,第一站淋巴结转移灶中的NF-кBp65及COX-2蛋白表达进行检测。结果:胃癌组织中NF-кBp65和COX-2蛋白表达在有淋巴结转移组的阳性表达率分别为79.55%和72.73%,大于无淋巴结转移组48.28%和41.38%,二者比较差异有显著性(P<0.01);NF-кBp65及COX-2蛋白在第一站淋巴结转移灶中的阳性表达率分别为95.45%和88.64%,高于胃癌原发灶81.82%和70.45%,两者比较差异有显著性(P<0.05)。结论:NF-кB和COX-2对于胃癌可能是一个与转移相关因子,通过调节相应的基因共同参与了胃癌的淋巴转移。

Objective：To study the expressions and clinical significance of NF-кB and COX-2 in gastric carcinoma tissues,and regional lymph nodes.Methods：To use S-P immunohistochemical technique to detect the expressions of protein NF-кBp65 and COX-2 in gastric carcinoma tissues,first station of lymph node and normal gastric mucosa.Results：The positive expression rate of NF-кBp65 and COX-2 of tumors with lymphoid nodes metastasis was 79.55% and 72.73%,which were higher than the expression rate of tumors without lymphoid nodes metastasis 48.28% and 41.38%（P 0.01） ;In lymph nodes metastatic foci,the positive rates of protein NF-кBp65 and COX-2（95.45% and 88.64%） were significantly higher than primary foci of gastric carcinoma（81.82% and 70.45%）（P 0.05）.Conclusion：NF-кB and COX-2 are likely related factors for gastric carcinoma metastasis,and play a certain role in lymph nodes metastatic.