卡培他滨联合顺铂治疗晚期胃癌临床疗效观察

Clinical observation of capecitabine combined with cisplatin in the treatment of advanced gastric carcinoma

目的:观察卡培他滨(希罗达)联合顺铂治疗晚期胃癌的疗效及不良反应。方法:采用口服卡培他滨1000mg/m2,每天2次,第1-14天,顺铂30mg/m2,静脉滴注,第1-3天,21天为1周期,连用2周期以后评价疗效。结果:28例晚期胃癌患者均可评价疗效,总有效率RR为53.6%,其中CR2例(7.1%),PR13例(46.4%),SD6例(21.4%),PD7例(25.0%)。不良反应为胃肠道反应Ⅰ-Ⅱ度,手足综合征Ⅰ-Ⅱ度。结论:卡培他滨联合顺铂治疗晚期胃癌近期疗效较好,不良反应较小,患者耐受性高,可改善患者的生存质量。

Objective：To evaluate the efficacy and adverse reaction of the chemotherapy capecitabine combined with cisplatin in the treatment of advanced gastric carcinoma.Methods：Twenty eight patients with advanced gastric carcinoma received oral capecitabine for 1000mg/m2,bid,d1-14,intravenous drip cisplatin 30mg/m2 d1-3,every three weeks for one cycle,evaluate the efficacy after 2 cycles.Results：To evaluate curative effect for 28 patients,2 CR,13 PR,6 SD,7 PD,short-term effective rate（CR ＋ PR） 53.6%.Adverse reaction was gastro-intestinal reactions grade Ⅰ-Ⅱ,hand-foot syndrome grade Ⅰ-Ⅱ.Conclusion：Clinical effect of combination of capecitabine plus cisplatin in treating advanced gastric carcinoma is good,the side effects were not severe,can improve the life quality.