精液凝固蛋白Semenogelin对精子运动抑制机制的研究进展

Semenogelin and sperm motility inhibition:An update

精液的液化和精子的获能是精子取得向前运动的关键,精液凝固蛋白Semenogelin(Sg)在这个过程中起着至关重要的作用,它们直接参与了精液凝胶的形成,并协同其他一些来源于男性生殖道的蛋白酶类和金属离子等,与精子细胞表面发生作用,参与调控精液液化和精子获能,最终使精子取得向前运动。本文综述了当前Sg对精子活动抑制机制的研究进展。

Semen liquefaction and sperm capacitation are the key processes for sperm to acquire forward movement ability.In these processes,semenogelin plays a vital role by directly participating in the formation of semen coagulation,collaborating with other protease and metal ions from the male reproductive tract,and then reacting with the surface of sperm cells,finally involved in the regulation of these processes and ensuring sperm＇s acquisition of forward movement ability.