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免疫抑制沙鼠源肺孢子菌的分类地位

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摘要 肺孢子菌能够感染多种哺乳动物的肺脏,并在免疫受抑制的个体引起肺孢子菌肺炎.研究表明,肺孢子菌分离株在系统进化树上分为两大枝,二者所含菌株分别来源于灵长类和啮齿类.基于宿主特异性以及DNA序列和形态学差异,每一分枝内的菌株又可分为不同的种.本研究采用地塞米松免疫抑制法,导致沙鼠(28/35)肺组织感染.对18S,5.8SrRNA和rRNA内转录间隔区基因序列,以及线粒体核糖体大亚基基因的部分序列分析表明,本实验沙鼠源肺孢子菌与啮齿类动物来源的同属一枝,但明显区别于其他啮齿类动物来源的菌株,应考虑是一个独立的菌种.
作者 冯宪敏 魏超君 Rodney D.Adam 李自慧 卢思奇
机构地区 吉林医药学院基础医学院病原教研室 首都医科大学寄生虫学教研室 Department of Medicine and Immunobiology 北京结核病胸部肿瘤研究所
出处 《中国科学：生命科学》 CSCD 北大核心 2010年第11期1055-1062,共8页 Scientia Sinica(Vitae)
基金 北京市自然科学基金(批准号:7052009)资助项目
关键词 肺孢子菌 长爪沙鼠 5.8S核糖体RNA基因 rRNA基因内转录间隔区 线粒体核糖体大亚基 18S核糖体RNA基因
分类号 Q939 [生物学—微生物学]
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参考文献22

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二级参考文献27

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中国科学：生命科学
2010年 第11期

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