摘要
目的 总结不明原因横纹肌溶解症患者的临床特点、治疗及预后.方法 回顾性分析2010年8月13日至2010年8月27日南京医科大学第一附属医院收治23例不明原因横纹肌溶解症患者临床特点、治疗及预后.结果 病史：发病前2～24 h有进食＂小龙虾＂史;临床表现：主要颈腰背躯干部及四肢肌肉疼痛、乏力、尿色改变等;实验室检查：血清肌酸激酶CK：（4655±2556）U/L（正常值为25～190 U/L）AST：（141±78）U/L（正常值为0～45 U/L）,LDH：（348±127）U/L（正常值为110～250U/L）和血清肌红蛋白Mb＞1000 μg/L（正常值为0～50 μg/L）;通过休息、补液、碱化尿液及预防并发症等治疗,无一例患者发生急性肾衰竭,所有患者均痊愈出院.结论 横纹肌溶解症是一种病因、临床表现和并发症多样的综合征,早期诊断和治疗,预防并发症的发生,患者预后较好.
Objective To evaluate clinical features, therapeutic regimen and prognosis of unexplained rhabdomyolysis. Method Clinical manifestations, therapeutic regimen and prognosis were recorded in 23 patients,who were admitted to The First Affiliated Hospital of Nanjing Medical University 13 to 27 August,2010.The 23 patients were diagnozed as unexplained rhabdomyolysis. Results The patients all presented myalgia of upper body,like neck,waist and back,maybe with asthenia, nausea,dyspnea,abdominal pain, red urine or changed color of urine. Laboratory examination： obviously step-up of creatine kinase [CK： （4655 ± 2556） U/L（ normal： 25 ～ 190U/L） AST：（141 ±78） U/L（normal：10～45 U/L）,LDH：（348± 127） U/L（normal： 110～ 250 U/L）]and myoglobin[（ Mb 〉 1000 μg/L （normal： 0 ～ 50 μg/L）]. Therapeutic regimen included treatment of the underlying diseases, volume repletion, alkalization and dealing with the complications. No patients developed acute renal failure.All the patients recovered. Conclusions Rhabdomyolysis is a syndrome with different clinical manifestations.However, early diagnosis, proper treatment could prevent serious complications,and prognosis is good.
出处
《中华急诊医学杂志》
CAS
CSCD
北大核心
2010年第10期1062-1065,共4页
Chinese Journal of Emergency Medicine
关键词
横纹肌溶解症
哈夫病
小龙虾
诊断
并发症
急性肾衰竭
血液净化
治疗
Rhabdomyolysis
Haff disease
Red swamp crayfish
Diagnosis
Complication
Acute renal failure
Blood purification
Treatment
