组织因子及其与心血管疾病的关系

对组织因子的认识已有百余年，尤其近20年来，它在动静脉血栓形成中的作用日益受到重视，对其复杂的生物学特性的了解也逐渐增多。组织因子（TissueFactor，TF）即第三凝血因子，又称组织凝血活酶，它既是凝血因子Ⅶ（FⅦ）的细胞表血受体，又是FⅦ或FⅦa的辅因子，它与F...

Tissue factor (TF, coagulation factor Ⅲ ) is distributed widely in extravascular tissues.It is a transmembrane glycoprotein located on the surface of a number of cell types and serves as an essential cofactor for factor Ⅶa. Blood cells and endothclial cells normally do not express TF. Various pathogenic agents can cause the dysfunction of endothelial cells and induce TF synthesis. The binding of plasma factor F Ⅶ /Ⅶ a to TF located on the surface of the cell may initiate activation of coagulation. The abnormal expression and release of TF in endothelial cells and subendothelial cells result from dysfunction of the endothelium can lead to the disorder of the coagulant fuction in the disease state. Thus, some cardiovascular disease associated with the hypercoagulant state and thrombosis will occur. In addition, TF, as a highaffinity receptor, participates in other cellular processes including intracellular signalling and tumor-associated angiogenesis. This brief review attcmpts to summarize present knowledge on the structure and fuction, in vivo and in vitro expression and release of TF and the gene regulation as well as the role thereof in the cardiovascular disease.