非甾体类消炎药相关性下消化道出血21例临床分析

Clinical analysis of 21 cases with NSAIDs associated lower gastrointestinal bleeding

目的探讨非甾体类消炎药(NSAIDs)相关性下消化道出血的临床特点。方法回顾性分析NSAIDs相关性下消化道出血21例患者的临床资料。结果NSAIDs相关性下消化道出血年龄较大,多有心脑血管病史,出血前临床症状不明显,出血量较大,使用生长抑素治疗效果较好;结肠镜检查多为小肠、结肠节段性浅溃疡,黏膜红斑、糜烂等表现。结论老年患有心脑血管疾病者易发NSAIDs相关性下消化道出血,且出血量较大,使用生长抑素治疗效果较好。及早进行结肠镜检查有助于明确诊断。

【Objective】To explore the clinical features of NSAIDs associated lower gastrointestinal bleeding. 【Methods】The clinical data of 21 patients with NSAIDs associated lower gastrointestinal bleeding were analyzed retrospectively. 【Results】The patients with NSAIDs associated lower gastrointestinal bleeding,who were the older and a great many of whom have the history of Cardiovascular and Cerebrovascular disease,have much Larger amount of bleeding,but they have not obvious clinical symptoms before bleeding. Using of somatostatin can get better treat-ment. The patients with NSAIDs associated lower gastrointestinal bleeding undergoing colonoscopy examination mostly have small intestine and colon segmental shallow ulcers,mucosal erythema,erosion and so on.【Conclu-sions】Elderly patients with Cardiovascular and Cerebrovascular diseases are prone to have NSAIDs associated lower gastrointestinal bleeding and have much Larger amount of bleeding,using of somatostatin can get better treatment. Early undergoing colonoscopy can help clarify the diagnosis.